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Article
Open AccessImproved Natural Killer cell activity and retained anti-tumor CD8+ T cell responses contribute to the induction of a pathological complete response in HER2-positive breast cancer patients undergoing neoadjuvant chemotherapy
Locally advanced HER2-overexpressing breast cancer (BC) patients achieve a high rate of pathological complete responses (pCR) after neoadjuvant chemotherapy (NC). The apparently unaltered immune proficiency of...
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Article
Open AccessThe role of Mediterranean diet on the risk of pancreatic cancer
The Mediterranean diet has been shown to have a beneficial role on various neoplasms, but data are scanty on pancreatic cancer.
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Article
Open AccessMetabolic syndrome and hepatocellular carcinoma risk
Hepatocellular carcinoma (HCC) has been associated to diabetes and obesity, but a possible association with the metabolic syndrome (MetS) and its potential interaction with hepatitis is open to discussion.
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Article
Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy
The aim of this study was to investigate the role of common polymorphisms in the nucleotide excision repair pathway genes in the tumorigenesis of osteosarcoma and in the response to DNA damaging therapies, suc...
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Article
Open AccessDietary intakes of carotenoids and other nutrients in the risk of nasopharyngeal carcinoma: a case–control study in Italy
Dietary habits have been related to the risk of nasopharyngeal carcinoma (NPC), but information on a wide range of macro- and micronutrients is still lacking, particularly for low-incidence countries.
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Article
Open AccessComment on ‘Lung cancer in the Swiss HIV Cohort Study: role of smoking, immunodeficiency and pulmonary infection’
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Adherence to the European food safety authority's dietary recommendations and colorectal cancer risk
The European Food Safety Authority (EFSA) recently published dietary guidelines for the intakes of carbohydrates, fiber, fats and water. We evaluated their role on the risk of a specific disease, known to be r...
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Article
Open AccessExposure to animals and increased risk of marginal zone B-cell lymphomas of the ocular adnexae
Ocular adnexal marginal zone B-cell lymphoma (OAMZL) has been associated with Chlamydophila psittaci, an infection that may be transmitted by carrier animals. However, it is still unclear whether exposure to anim...
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Article
Open AccessUrinary human polyomavirus and papillomavirus infection and bladder cancer risk
The association of transitional cell carcinomas of the bladder (TCB) with Schistosoma haematobium suggested a possible role of infections in the aetiology of TCB.
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Article
Open AccessAnthropometric measures at different ages and endometrial cancer risk
Endometrial cancer is strongly associated with body mass index (BMI), but the influence of BMI history and of different types of obesity is uncertain.
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Article
Life course social mobility and risk of upper aerodigestive tract cancer in men
The aim of this study was to explore associations between social mobility and tumours of the upper aero-digestive tract (UADT), focussing on life-course transitions in social prestige (SP) based on occupationa...
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Article
Open AccessDiabetes and endometrial cancer: effect modification by body weight, physical activity and hypertension
Among 777 endometrial cancer cases and 1550 controls from Italy and Switzerland, odds ratio was 1.7 (95% confidence interval: 1.2–2.5) for diabetes, and 5.1 for obese diabetic women as compared with non-obese ...
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Article
HCV-NS3 and IgG-Fc crossreactive IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferations
We demonstrate that in three cases of MC (two with immunocytoma), the IgM-RF+ component of their cryoprecipitated represents the circulating counterpart of the B-cell receptor (BCR) of the monoclonal overexpan...
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Article
History of weight and obesity through life and risk of benign prostatic hyperplasia
The relation of anthropometric measures, diabetes, hypertension and hyperlipidemia with benign prostatic hyperplasia (BPH) risk was investigated.
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Article
Open AccessRole of fried foods and oral/pharyngeal and oesophageal cancers
We investigated the role of fried foods on oral-pharyngeal and oesophageal cancers, using data from two case–control studies conducted in Italy and Switzerland between 1992 and 1999, one with a total of 749 (6...
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Article
Open AccessProstate cancer and body size at different ages: an Italian multicentre case–control study
We investigated the influence of anthropometric measures at diagnosis and at different ages on prostate cancer risk using an Italian multicentre case–control study conducted between 1991 and 2002 of 1294 histo...
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Article
Open AccessCholecystectomy and the risk of colorectal cancer in Italy
In two case–control studies from Italy covering 3533 cases of colorectal cancer and 7062 hospital controls, the odds ratios were 1.04 after cholecystectomy for colorectal, 1.08 for colon and 1.03 for rectal ca...
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Article
Mitoxantrone, vinorelbine and prednisone (MVD) in the treatment of metastatic hormonoresistant prostate cancer — a phase II trial
A total of 28 patients were treated with mitoxantrone, vinorelbine and prednisone every 3 weeks. In all, 11 patients (46%) had a significant prostate-specific antigen decline for a median duration of 11.4 mont...
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Article
Open AccessAspirin use and cancers of the upper aerodigestive tract
The role of aspirin on the risk of cancers of the upper aerodigestive tract was investigated in the combined data of three Italian case–control studies, including 965 cases and 1779 hospital controls. The odds...
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Article
Combined effect of tobacco and alcohol on laryngeal cancer risk: a case–control study
Objective: To provide information on the effects of alcohol and tobacco on laryngeal cancer and its subsites. Methods: This was a case–control study conducted between 1992 and 2000 in northern Italy and Switzerl...
