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  1. Article

    Open Access

    Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention

    Scientists have long sought to characterize the pathophysiologic basis of schizophrenia and develop biomarkers that could identify the illness. Extensive postmortem and in vivo neuroimaging research has described...

    J A Lieberman, R R Girgis, G Brucato, H Moore, F Provenzano… in Molecular Psychiatry (2018)

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  2. No Access

    Article

    Imaging glutamate in schizophrenia: review of findings and implications for drug discovery

    Currently, all treatments for schizophrenia (SCZ) function primarily by blocking D2-type dopamine receptors. Given the limitations of these medications, substantial efforts have been made to identify alternative ...

    E M P Poels, L S Kegeles, J T Kantrowitz, M Slifstein, D C Javitt… in Molecular Psychiatry (2014)

  3. No Access

    Article

    Striatal dopamine release in schizophrenia comorbid with substance dependence

    Dopamine (DA) has a role in the pathophysiology of schizophrenia and addiction. Imaging studies have indicated that striatal DA release is increased in schizophrenia, predominantly in the precommissural caudat...

    J L Thompson, N Urban, M Slifstein, X Xu, L S Kegeles, R R Girgis… in Molecular Psychiatry (2013)

  4. No Access

    Article

    Antipsychotic drug mechanisms: links between therapeutic effects, metabolic side effects and the insulin signaling pathway

    The exact therapeutic mechanism of action of antipsychotic drugs remains unclear. Recent evidence has shown that second-generation antipsychotic drugs (SGAs) are differentially associated with metabolic side e...

    R R Girgis, J A Javitch, J A Lieberman in Molecular Psychiatry (2008)