![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessHippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention
Scientists have long sought to characterize the pathophysiologic basis of schizophrenia and develop biomarkers that could identify the illness. Extensive postmortem and in vivo neuroimaging research has described...
-
Article
Imaging glutamate in schizophrenia: review of findings and implications for drug discovery
Currently, all treatments for schizophrenia (SCZ) function primarily by blocking D2-type dopamine receptors. Given the limitations of these medications, substantial efforts have been made to identify alternative ...
-
Article
Striatal dopamine release in schizophrenia comorbid with substance dependence
Dopamine (DA) has a role in the pathophysiology of schizophrenia and addiction. Imaging studies have indicated that striatal DA release is increased in schizophrenia, predominantly in the precommissural caudat...
-
Article
Antipsychotic drug mechanisms: links between therapeutic effects, metabolic side effects and the insulin signaling pathway
The exact therapeutic mechanism of action of antipsychotic drugs remains unclear. Recent evidence has shown that second-generation antipsychotic drugs (SGAs) are differentially associated with metabolic side e...