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Article
A system for manually or automatically controlled gustatory stimulation
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Article
Oral absorption of cimetidine and its clearance in patients with renal failure
The plasma concentration curve after a single oral dose of cimetidine 200 mg was followed in 27 patients with varying degrees of chronic renal failure (creatinine clearance 1–52 ml/min) and in 46 patients with...
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Article
Catalytic hydrogenation of soybean oil with Rh(l) dihydride complexes as catalysts
Cationic rhodium(I) complexes of the type [NBD Rh L2]+[C1O4]− (NBD = norbornadiene and L = diphenylphosphinoethane or triphenylphosphine) have been studied as catalysts for the hydrogenation of soybean oil. These...
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Article
Investigations on the conditions for hydrogenation of fatty oils with polymer anchored pd-phosphine complexes
Palladium chloride has been anchored to phosphinated, cross-linked polystyrene by substitution of the pyridine ligand in Cl2 Pd-(NC5H5)2 with the polymeric phosphine. By analytical and infrared studies of the pre...
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Article
The electrochemical properties of imidazol-linked iron phthalocyanine—carbon electrodes
Electrodes for the electrochemical reduction of oxygen have been studied galvanostatically. The electrodes were of the activated carbon-polymeric iron phthalocyanine (FePc) type, made hydrophobic with a Teflon...
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Article
Pharmacokinetics of cimetidine and its sulphoxide metabolite during haemodialysis
A single intravenous dose of cimetidine 200mg was administered to 6 patients with severe chronic renal failure one hour prior to haemodialysis. The plasma concentrations of cimetidine and its sulphoxide metabo...
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Article
Hydrogenation theory: Some aspects
The model of associate adsorption of olefinic groups to give the half-hydrogenated state suggested first by Horiuti and Polanyi, gives the simplest possible description of the hydrogenation process. By adding ...
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Article
X-ray photoelectron spectra and electrochemical properties of imidazol-linked iron phthalocyanine carbon electrode systems
Electrodes for the electrochemical reduction of oxygen have been studied both galvanostatically and by XPS and IR spectroscopy. The electrodes contain a polymeric phthalocyanine catalyst fixed to an activated ...
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Article
Prizidilol, a combined vasodilatory and β-adrenoceptor blocking drug, in primary hypertension
After an initial placebo period of four weeks 24 patients with primary hypertension were treated with prizidilol, a hydrazinopyridazine derivative with combined vasodilator and non-selective beta-adrenoceptor ...
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Article
Pharmacokinetics of enprofylline in patients with impaired renal function after a single intravenous dose
Enprofylline, a new bronchodilating drug, was given i.v. at 1.0 mg/kg to 7 healthy subjects and to 14 patients with differing degrees of chronic renal insufficiency. Plasma and urine concentrations of unchange...
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Chapter
Quinone Imines as Biological Reactive Intermediates
Quinone imines represent a class of biological reactive intermediates that has been the focus of intensive toxicological research in recent years. Two representative quinone imines that have been subjects of r...
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Article
The electronic structure of a series of tin complexes studied by XPS and Mössbauer spectroscopy
The isomer shift and 3d5/2 core electron binding energy shift have been measured for a series of complexes. By using a simple model for the interpretation of these shifts in terms of occupation numbers of valence...
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Article
Effects of probenecid on enprofylline kinetics in man
Enprofylline 1 mg/kg, a new potent antiasthmatic xanthine derivative, which is mainly eliminated by renal excretion, was given intravenously to 6 normal subjects with and without oral pretreatment with 1 g pro...
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Article
Pharmacokinetics and effects on blood pressure of a single oral dose of milrinone in healthy subjects and in patients with renal impairment
Milrinone, a new, nonglycosidic inotropic agent with peripheral vasodilating properties, was given as a single oral 5 mg dose to 7 healthy subjects, 7 patients with moderate renal impairment (CRI I, creatinine...
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Article
Cytoplasmic Ca2+ concentration of single normal human and bovine parathyroid cells measured by dual wavelength microfluorometry
Dual wavelength microfluorometry was utilized to measure the cytoplasmic calcium concentration (Cai 2+) of single parathyroid cells loaded with the indicator fura-2. The method enabled the first registrations of ...
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Article
Verapamil and cyclosporin a sensitize human kidney tumor cells to vincristine in absence of membrane P-glycoprotein and without apparent changes in the cytoplasmic free Ca2+ concentration
Vincristine (Vcr) dose dependently inhibited growth of the kidney adenocarcinoma cell line ACHN during 4 days of culture. Verapamil (Ver) at 10 μM and cyclosporin A (CsA) at 1 μg/ml had no effect on cell growt...
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Article
Chemically regenerative redox fuel cells. I Membrane studies
Three different types of membrane have been tested in a chemically regenerative redox fuel cell. It was found that a Nafion membrane gave the best polarization curves, but also that a much cheaper silica-fille...
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Article
Doxorubicin selected multidrug-resistant small cell lung cancer cell lines characterised by elevated cytoplasmic Ca2+ and resistance modulation by verapamil in absence of P-glycoprotein overexpression
Sublines from the small cell lung cancer (SCLC) cell lines U1285 and U1690, denoted U1285-100, U1285-250, U1690-40 and U1690-150, were adapted to grow in the continuous presence of 100, 250, 40 and 150 ng ml-1...
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Chapter
Numerical Simulation of Plastic Localization Using Fe-Mesh Realignment
Proper design of the computational algorithm is absolutely essential in order to account for the failure mechanisms that are responsible for the development of a strongly localized mode of deformation. In this...
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Article
In vitro testing of chemotherapeutic drug combinations in acute myelocytic leukaemia using the fluorometric microculture cytotoxicity assay (FMCA)
The fluorometric microculture cytotoxicity assay (FMCA) was employed for analysing the effect of different chemotherapeutic drug combinations and their single constituents in 44 cases of acute myelocytic leuka...
