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Article
Open AccessA phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer
Mebendazole is used extensively for treatment of local gut helminthic and invasive echinococcus infections. Anticancer effects of mebendazole have been shown in experimental cancer models and in case studies i...
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Article
Correction to: Friction Reduction in Elastohydrodynamic Contacts by Thin-Layer Thermal Insulation
The original version of this article unfortunately contained a mistake. The correct information is given below.
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Article
Open AccessAbsolute Measurement of Elastic Waves Excited by Hertzian Contacts in Boundary Restricted Systems
In most applied monitoring investigations using acoustic emission, measurements are carried out relatively, even though that limits the use of the extracted information. The authors believe acoustic emission m...
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Article
Open AccessElastic Waves of a Single Elasto-Hydrodynamically Lubricated Contact
Elastic waves are widely used for condition monitoring of rolling element bearings through vibration or acoustic emission measurements . While vibration signals are understood to a high degree due to many scie...
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Article
Open AccessMonitoring of Running-in of an EHL Contact Using Contact Impedance
Running-in is an important process for elasto-hydrodynamic lubricated contacts, which affect both service life and operating performance. However, the possibilities of monitoring running-in are still poor. The...
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Article
Open AccessIn vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index
In vitro-based search for promising anti-cancer drug combinations may provide important leads to improved cancer therapies. Currently there are no integrated computational-experimental methods specifically design...
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Article
Open AccessDrug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia
To find drugs suitable for repositioning for use against leukemia, samples from patients with chronic lymphocytic, acute myeloid and lymphocytic leukemias as well as peripheral blood mononuclear cells (PBMC) w...
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Article
Open AccessThe Effect of DLC Coating Thickness on Elstohydrodynamic Friction
The application of surface coatings has been shown to reduce friction in elastohydrodynamic lubrication (EHL), not only in the mixed and boundary regime when asperity interactions occur, but also in the full f...
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Article
Friction Reduction in Elastohydrodynamic Contacts by Thin-Layer Thermal Insulation
Reducing friction is of utmost importance to improve efficiency and lifetime of many products used in our daily lives. Thin hard coatings like diamond-like carbon (DLC) have been shown to reduce friction in fu...
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Article
3-Axis magnetic control: flight results of the TANGO satellite in the PRISMA mission
PRISMA implements guidance, navigation and control strategies for advanced formation flying and rendezvous experiments. The project is funded by the Swedish National Space Board and run by OHB-Sweden in close ...
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Article
The Influence of DLC Coating on EHL Friction Coefficient
High hardness, high elastic modulus, low friction characteristics, high wear and corrosion resistance, chemical inertness, and thermal stability are factors that make diamond-like carbon (DLC) coatings the sub...
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Article
Open AccessThe novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia
Aberrantly expressed tyrosine kinases have emerged as promising targets for drug development in acute myeloid leukemia (AML). We report that AKN-028, a novel tyrosine kinase inhibitor (TKI), is a potent FMS-li...
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Article
Map** of quick clay formations using geotechnical and geophysical methods
Quick clay has been involved in most serious, large clay slides in Sweden, Norway, and Canada. This paper describes geotechnical and geophysical methods that can be used to locate and map the extent of quick c...
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Article
Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids
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Chapter
Planning for River Induced Floods in Urban Areas
Problems in urban areas due to flooding are minor in Sweden from an international perspective. However, some events during the last decade have caused considerable damage which has drawn national attention to ...
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Article
Open AccessIdentification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles
Acquired drug resistance is a major problem in cancer treatment. To explore the genes involved in chemosensitivity and resistance, 10 human tumour cell lines, including parental cells and resistant subtypes se...
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Article
Translocation t(1;19) is related to low cellular drug resistance in childhood acute lymphoblastic leukaemia
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Article
Small, novel proteins from the mistletoe Phoradendron tomentosum exhibit highly selective cytotoxicity to human breast cancer cells
Four novel proteins (phoratoxins C–F) have been isolated from the North American mistletoe Phoradendron tomentosum. The amino acid sequences of these phoratoxins were determined unambiguously using a combination...
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Chapter and Conference Paper
Localization Analysis of a Saturated Elastic Plastic Porous Medium Based on Regularized Discontinuity
In the present paper we analyze the conditions for band-shaped localization to occur in the hydro-mechanically coupled problem. In the localization analysis, the concept of regularized discontinuity is used at...
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Chapter and Conference Paper
On the Analysis of Adiabatic Strong Discontinuities within Thermoplastic Solids
