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Article
Open AccessIdentification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles
Acquired drug resistance is a major problem in cancer treatment. To explore the genes involved in chemosensitivity and resistance, 10 human tumour cell lines, including parental cells and resistant subtypes se...
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Article
Open AccessThe novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia
Aberrantly expressed tyrosine kinases have emerged as promising targets for drug development in acute myeloid leukemia (AML). We report that AKN-028, a novel tyrosine kinase inhibitor (TKI), is a potent FMS-li...
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Article
Open AccessThe Effect of DLC Coating Thickness on Elstohydrodynamic Friction
The application of surface coatings has been shown to reduce friction in elastohydrodynamic lubrication (EHL), not only in the mixed and boundary regime when asperity interactions occur, but also in the full f...
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Article
Open AccessDrug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia
To find drugs suitable for repositioning for use against leukemia, samples from patients with chronic lymphocytic, acute myeloid and lymphocytic leukemias as well as peripheral blood mononuclear cells (PBMC) w...
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Article
Open AccessIn vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index
In vitro-based search for promising anti-cancer drug combinations may provide important leads to improved cancer therapies. Currently there are no integrated computational-experimental methods specifically design...
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Article
Open AccessMonitoring of Running-in of an EHL Contact Using Contact Impedance
Running-in is an important process for elasto-hydrodynamic lubricated contacts, which affect both service life and operating performance. However, the possibilities of monitoring running-in are still poor. The...
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Article
Open AccessElastic Waves of a Single Elasto-Hydrodynamically Lubricated Contact
Elastic waves are widely used for condition monitoring of rolling element bearings through vibration or acoustic emission measurements . While vibration signals are understood to a high degree due to many scie...
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Article
Open AccessAbsolute Measurement of Elastic Waves Excited by Hertzian Contacts in Boundary Restricted Systems
In most applied monitoring investigations using acoustic emission, measurements are carried out relatively, even though that limits the use of the extracted information. The authors believe acoustic emission m...
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Article
Correction to: Friction Reduction in Elastohydrodynamic Contacts by Thin-Layer Thermal Insulation
The original version of this article unfortunately contained a mistake. The correct information is given below.
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Article
Open AccessA phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer
Mebendazole is used extensively for treatment of local gut helminthic and invasive echinococcus infections. Anticancer effects of mebendazole have been shown in experimental cancer models and in case studies i...
