16 Result(s)

Article

Influence of arginase polymorphisms and arginase levels/activity on the response to erectile dysfunction therapy with sildenafil

Arginase 1 (ARG1) and arginase 2 (ARG2) compete with nitric oxide synthases for the substrate l-arginine. Here we aim to assess whether arginase 1 and 2 plasma levels, plasma arginase activity or genetic factors ...

R Lacchini, J J Muniz, Y T D A Nobre, A J Cologna… in The Pharmacogenomics Journal (2018)

Article

Gene–gene interactions in the NAMPT pathway, plasma visfatin/NAMPT levels, and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy

Nicotinamide phosphorybosil transferase (NAMPT) polymorphisms affect visfatin/NAMPT levels and may affect the responsiveness to therapy in hypertensive disorders of pregnancy. We examined whether NAMPT polymorphi...

M R Luizon, A C T Palei, V A Belo, L M Amaral, R Lacchini… in The Pharmacogenomics Journal (2017)

Article

In reply to: Enalapril and the VEGFA gene: personalized medicine in hypertension therapy

G. H. Oliveira-Paula, R. Lacchini… in European Journal of Clinical Pharmacology (2016)

Article

Polymorphisms in VEGFA gene affect the antihypertensive responses to enalapril

Vascular endothelial growth factor (VEGF) is a potent angiogenic factor that affects blood pressure by promoting vasodilation mediated by nitric oxide. Angiotensin-converting enzyme inhibitors (ACEi) up-regula...

G. H. Oliveira-Paula, R. Lacchini, V. Fontana… in European Journal of Clinical Pharmacology (2015)

Article

The effects of endothelial nitric oxide synthase tagSNPs on nitrite levels and risk of hypertension and obesity in children and adolescents

Obesity and the nitric oxide synthase 3 (NOS3) gene polymorphisms are associated with nitrite levels and hypertension. However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs7435...

J A de Miranda, R Lacchini, V A Belo, C M M Lanna… in Journal of Human Hypertension (2015)

Article

The effects of NAMPT haplotypes and metabolic risk factors on circulating visfatin/NAMPT levels in childhood obesity

Polymorphisms in the NAMPT gene, which encodes the adipocytokine visfatin/nicotinamide phosphorybosil transferase (NAMPT), affect the circulating visfatin/NAMPT levels and are associated with obesity and cardiova...

V A Belo, M R Luizon, R Lacchini, J A Miranda… in International Journal of Obesity (2015)

Article

Tissue inhibitor of matrix metalloproteinase-1 polymorphism, plasma TIMP-1 levels, and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy

Tissue inhibitor of metalloproteinase (TIMP)-1 is a major endogenous inhibitor of matrix metalloproteinase (MMP)-9, which may affect the responsiveness to therapy in hypertensive disorders of pregnancy. We examin...

M R Luizon, A C T Palei, V C Sandrim, L M Amaral… in The Pharmacogenomics Journal (2014)

Article

VEGF genetic polymorphisms affect the responsiveness to sildenafil in clinical and postoperative erectile dysfunction

Vascular endothelial growth factor (VEGF) is a cytokine involved in angiogenesis and is closely related to the nitric oxide–cyclic guanosine monophosphate pathway, a target for sildenafil. We investigated for ...

R Lacchini, J J Muniz, Y T D A Nobre, A J Cologna… in The Pharmacogenomics Journal (2013)

Article

Haptoglobin polymorphism affects nitric oxide bioavailability in preeclampsia

Studies showed elevated cell-free hemoglobin (Hb) in preeclampsia (PE), and Hb reacts with nitric oxide (NO), decreasing its bioavailability. Haptoglobin (Hp) is a polymorphic protein (Hp1-1, Hp2-1 and Hp2-2) ...

J T Sertório, R Lacchini, L M Amaral, A C T Palei… in Journal of Human Hypertension (2013)

Article

Adiponectin associates positively with nitrite levels in children and adolescents

To compare the circulating levels of adiponectin and nitric oxide (NO) bioavailability in eutrophic, eutrophic hypertensive, obese, and obese hypertensive children and adolescents, and to assess whether adipon...

V A Belo, D C Souza-Costa, R Lacchini, J T Sertório… in International Journal of Obesity (2013)

Article

Endothelial nitric oxide synthase genotypes and haplotypes modify the responses to sildenafil in patients with erectile dysfunction

Erectile dysfunction (ED) is usually treated with sildenafil. Although genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may impair endogenous NO formation, there is little information ab...

J J Muniz, R Lacchini, T O Rinaldi, Y T D A Nobre… in The Pharmacogenomics Journal (2013)

Article

eNOS and BDKRB2 genotypes affect the antihypertensive responses to enalapril

The antihypertensive effect of angiotensin-converting enzyme inhibitors (ACEi) is attributed partially to increased nitric oxide bioavailability. It is possible that functional polymorphisms in endothelial nit...

P. S. Silva, V. Fontana, M. R. Luizon… in European Journal of Clinical Pharmacology (2013)

Article

Matrix metalloproteinase-9 polymorphisms affect plasma MMP-9 levels and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy

Abnormal matrix metalloproteinase (MMP)-9 levels may have a role in hypertensive disorders of pregnancy. We examined whether MMP-9 genetic polymorphisms (g.−1562C>T and g.−90(CA)₁₃₋₂₅) modify plasma MMP-9 and tis...

A C T Palei, V C Sandrim, L M Amaral, J S R Machado… in The Pharmacogenomics Journal (2012)

Article

Common matrix metalloproteinase 2 gene haplotypes may modulate left ventricular remodelling in hypertensive patients

Matrix metalloproteinases (MMPs) are involved in cardiac remodelling. We examined whether MMP-2 genetic polymorphisms are associated with hypertension and left ventricular (LV) remodelling in hypertensive pati...

R Lacchini, A L B Jacob-Ferreira, M R Luizon, S Gasparini… in Journal of Human Hypertension (2012)

Article

Circulating matrix metalloproteinases and their endogenous inhibitors in patients with erectile dysfunction

Erectile dysfunction (ED) may reflect vascular alterations associated with imbalanced matrix metalloproteinases (MMPs) activities. However, no previous study has compared MMPs levels in ED patients with those ...

J J Muniz, R Lacchini, V A Belo… in International Journal of Impotence Research (2012)