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  1. Article

    Open Access

    Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α

    Non-alcoholic steatohepatitis (NASH) is a severe type of the non-alcoholic fatty liver disease (NAFLD). NASH is a growing global health concern due to its increasing morbidity, lack of well-defined biomarkers ...

    Jialin **a, Hong Chen, **aoxiao Wang, Weixuan Chen, Jun Lin… in Nature Communications (2024)

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  2. No Access

    Article

    The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice

    Polycystic ovary syndrome (PCOS), an endocrine disorder afflicting 6–20% of women of reproductive age globally, has been linked to alterations in the gut microbiome. We previously showed that in PCOS, elevatio...

    Chuyu Yun, Sen Yan, Baoying Liao, Yong Ding, **nyu Qi, Min Zhao… in Nature Metabolism (2024)

  3. No Access

    Article

    Comprehensive insights: unraveling the mechanisms of gut commensals in glucose metabolism regulation

    Zhipeng Li, Qixing Nie, Shao-** Nie in Science China Life Sciences (2024)

  4. Article

    Open Access

    Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a

    Gut microbiota plays a key role in insulin resistance (IR). Here we perform a case-control study of Chinese adults (ChiCTR2200065715) and identify that Parabacteroides distasonis is inversely correlated with IR. ...

    Yonggan Sun, Qixing Nie, Shanshan Zhang, Huijun He, Sheng Zuo… in Nature Communications (2023)

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  5. No Access

    Article

    Gut bacteria alleviate smoking-related NASH by degrading gut nicotine

    Tobacco smoking is positively correlated with non-alcoholic fatty liver disease (NAFLD)1–5, but the underlying mechanism for this association is unclear. Here we report that nicotine accumulates in the intestine ...

    Bo Chen, Lulu Sun, Guangyi Zeng, Zhe Shen, Kai Wang, Limin Yin, Feng Xu… in Nature (2022)

  6. No Access

    Article

    Hypoglycemic mechanism of polysaccharide from Cyclocarya paliurus leaves in type 2 diabetic rats by gut microbiota and host metabolism alteration

    Diabetes mellitus is a serious threat to human health. Cyclocarya paliurus (Batal.) Il**skaja (C.paliurus) is one of the traditional herbal medicine and food in China for treating type 2 diabetes, and the C. pal...

    Qiqiong Li, Jielun Hu, Qixing Nie, **ao Chang, Qingying Fang… in Science China Life Sciences (2021)