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  1. Article

    Open Access

    c-di-GMP inhibits the DNA binding activity of H-NS in Salmonella

    Cyclic di-GMP (c-di-GMP) is a second messenger that transduces extracellular stimuli into cellular responses and regulates various biological processes in bacteria. H-NS is a global regulatory protein that rep...

    Shuyu Li, Qinmeng Liu, Chongyi Duan, Jialin Li, Hengxi Sun, Lei Xu in Nature Communications (2023)

  2. Article

    Open Access

    Autoinducer-2 and bile salts induce c-di-GMP synthesis to repress the T3SS via a T3SS chaperone

    Cyclic di-GMP (c-di-GMP) transduces extracellular stimuli into intracellular responses, coordinating a plethora of important biological processes. Low levels of c-di-GMP are often associated with highly virule...

    Shuyu Li, Hengxi Sun, Jianghan Li, Yujiao Zhao, Ruiying Wang in Nature Communications (2022)

  3. Article

    Open Access

    Exploring AI-2-mediated interspecies communications within rumen microbial communities

    The rumen is an ecosystem with a complex microbial microflora in which microbes initiate biofilm formation by attaching to plant surfaces for plant degradation and are capable of converting feed to nutrients a...

    **aozhen Liu, Qinmeng Liu, Sihuai Sun, Hengxi Sun, Yao Wang, **hui Shen in Microbiome (2022)

  4. Article

    Open Access

    Sensing of autoinducer-2 by functionally distinct receptors in prokaryotes

    Autoinducer-2 (AI-2) is a quorum sensing signal that mediates communication within and between many bacterial species. However, its known receptors (LuxP and LsrB families) are not found in all the bacteria ca...

    Lei Zhang, Shuyu Li, **aozhen Liu, Zhuo Wang, Mei Jiang in Nature Communications (2020)