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  1. Article

    Open Access

    Fotagliptin monotherapy with alogliptin as an active comparator in patients with uncontrolled type 2 diabetes mellitus: a randomized, multicenter, double-blind, placebo-controlled, phase 3 trial

    Dipeptidyl peptidase-4 inhibitors (DPP-4i) have become firmly established in treatment algorithms and national guidelines for improving glycemic control in type 2 diabetes mellitus (T2DM).To report the finding...

    Mingtong Xu, Kan Sun, Wenjie Xu, Chuan Wang, Dewen Yan, Shu Li, Li Cong… in BMC Medicine (2023)

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  2. No Access

    Article

    The role of CXCL8 and CCNB1 in predicting hepatocellular carcinoma in the context of cirrhosis: implications for early detection and immune-based therapies

    Cirrhosis is a serious condition characterized by the replacement of healthy liver tissue with scar tissue, which can progress to liver failure if left untreated. Hepatocellular carcinoma (HCC) is a concerning...

    Qingyuan Sun, Ran An, **gxin Li… in Journal of Cancer Research and Clinical On… (2023)

  3. Article

    Open Access

    LncRNA5251 inhibits spermatogenesis via modification of cell-cell junctions

    Male factors-caused decline in total fertility has raised significant concern worldwide. LncRNAs have been identified to play various roles in biological systems, including spermatogenesis. This study aimed to...

    Cong Zhang, Dongxin Lu, Tong Niu, Zhongyi Sun, Yandi Wang, **ao Han… in Biology Direct (2023)

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  4. Article

    Open Access

    Gut microbiota-testis axis: FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes

    Clinical data suggest that male reproductive dysfunction especially infertility is a critical issue for type 1 diabetic patient (T1D) because most of them are at the reproductive age. Gut dysbiosis is involved...

    Yanan Hao, Yanni Feng, **aowei Yan, Liang Chen, Ruqing Zhong… in Molecular Medicine (2022)

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  5. Article

    Open Access

    Establishment and biological characteristics of fibroblast cell lines obtained from wild corsac fox

    **he Li, Yunxia Li, **aojie Yan, **aonan Guo… in In Vitro Cellular & Developmental Biology … (2020)

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  6. Article

    Open Access

    Epigenetic changes associated with oocyte aging

    It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age. Poor oocyte quality is correlated with compromised genetic integr...

    **ngWei Liang, JunYu Ma, Heide Schatten, QingYuan Sun in Science China Life Sciences (2012)

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  7. No Access

    Article

    Replacement of inner cell mass in mouse

    The intraor inter-strain reconstituted blastocysts were produced by replacing the inner cell mass of Kunming mouse blastocysts with that of Kunming or C57BL/6 mouse strain blastocysts. A total of 192 intra-str...

    Chunming Bi, Duancheng Wen, Ying Xu, Qingyuan Sun, Dayuan Chen in Chinese Science Bulletin (2003)

  8. No Access

    Article

    Somatic cell bovine cloning: Effect of donor cell and recipients

    Adult somatic cell nuclear transfer was conducted by using cultured ear fibroblast cells obtained from a Holstein female cow (GN) and a Galoway herd bull (GLV). The percentages of reconstructed eggs developed ...

    Dayuan Chen, **song Li, Zhiming Han, Lei Lei, Zhonghua Liu… in Chinese Science Bulletin (2003)

  9. No Access

    Article

    Roles of MAP kinase signaling pathway in oocyte meiosis

    Mitogen-activated protein kinase (MAPK) is a family of Ser/Thr protein kinases expressed widely in eukaryotic cells. MAPK is activated by a cascade of protein kinase phosphorylation and plays pivotal roles in ...

    Hengyu Fan, Chao Tong, Dayuan Chen, Qingyuan Sun in Chinese Science Bulletin (2002)

  10. No Access

    Article

    MAPK regulates cell cycle progression in pig oocytes and fertilized eggs

    Oocytes collected from prepubertal gilt ovaries were matured in vitro (IVM), and fertilized in vitro (IVF) or electrically activated. Phosphorylation of mitogenactivated protein kinase (MAPK) was detected with SD...

    Manyu Li, Hengyu Fan, Chao Tong, Dayuan Chen, Guoliang **a… in Chinese Science Bulletin (2002)

  11. No Access

    Article

    Serial nuclear transfer improves the development of interspecies reconstructed giant panda (Aluropoda melanoleuca) embryos

    Interspecies somatic nuclear transfer (NT) may provide a new approach for preservation of the endangered rare species. Previous interspecies cloning studies have shown that a nucleus from a quiescent somatic c...

    **song Li, Dayuan Chen, Zhiming Han, Ziyu Zhu, Duancheng Wen… in Chinese Science Bulletin (2002)

  12. No Access

    Article

    Microsatellite DNA analysis proves nucleus of interspecies reconstructed blastocyst coming from that of donor giant panda

    A method for DNA isolation from early development of blastocyst and further analysis of nuclear and mitochondrial DNA was developed in present study. Total DNA was prepared from interspecies reconstructed blas...

    Bo Ding, Peng Shi, **ggong **angyu, Ya** Zhang, Dayuan Chen… in Chinese Science Bulletin (2000)

  13. No Access

    Article

    Nuclear transfer using nonquiescent adult fibroblasts from a bovine ear

    The natural reproduction of mammal is sexual reproduction, which needs fertilization involving sperm and oocyte. Nuclear transfer provided an asexual reproduction method for mammal. Donor cells used in previou...

    Jilong Liu, Minkang Wang, Li Lian, **song Li, Shaorong Gao… in Chinese Science Bulletin (1999)

  14. No Access

    Article

    Sperm antigen MSH27 participates in sperm-egg membrane fusion

    A monoclonal antibody (mAb), MSH27 has been selected from an mAb library which has been prepared with separated mouse sperm heads as antigens. Three aspects of evidence indicated that the MSH27 antigen was inv...

    Dazhong Zhuang, **angfen Song, Guojun Hu, Qingyuan Sun… in Chinese Science Bulletin (1999)

  15. No Access

    Article

    The giant panda (Ailuropoda melanoleuca) somatic nucleus can dedifferentiate in rabbit ooplasm and support early development of the reconstructed egg

    The giant panda skeletal muscle cells, uterus epithelial cells and mammary gland cells from an adult individual were cultured and used as nucleus donor for the construction of intenpecies embryos by transferri...

    Dayuan Chen, Qingyuan Sun, Jilong Liu… in Science in China Series C: Life Sciences (1999)

  16. No Access

    Article

    Subzonal insemination with primary spermatocytes in mouse

    Ling Liu, Qingyuan Sun, Chongwen Duan, Hui Liu, **angfen Song… in Chinese Science Bulletin (1997)

  17. No Access

    Article

    Applying bases for “double control” artificial breeding of giant panda in captivity

    Dayuan Chen, **angfen Song, Chongwen Duan, Mingwen Li… in Chinese Science Bulletin (1997)

  18. No Access

    Article

    Subzonal fertilization of mouse round spermatids

    Mouse round spermatids were electrofused with homologous mature oocytes to examine the behaviour of their nuclei within the ooplasm and the abilities of development. A single spermatid was injected in the peri...

    Ling Liu, Qingyuan Sun, Chongwen Duan, Hui Liu… in Science in China Series C: Life Sciences (1997)