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  1. No Access

    Article

    Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion

    Genetic deletion of HDAC3, a circadian epigenome regulator, specifically in skeletal muscle alters amino acid metabolism, leading to increased muscle endurance but at the cost of whole-body insulin resistance.

    Sungguan Hong, Wenjun Zhou, Bin Fang, Wenyun Lu, Emanuele Loro… in Nature Medicine (2017)

  2. No Access

    Article

    A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

    Fatty acid transport from blood vessels to skeletal muscle, across endothelial cells, is regulated by the branched chain amino acid metabolite 3-hydroxy-isobutyrate. This finding provides a mechanistic explana...

    Cholsoon Jang, Sungwhan F Oh, Shogo Wada, Glenn C Rowe, Laura Liu… in Nature Medicine (2016)

  3. No Access

    Article

    Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

    The insulin signaling pathway regulating glucose homeostasis that has been well accepted is insulin-to-insulin receptor-to-IRS proteins-to-PI3K-to-Akt-to-Foxo1—a pathway that does not respond properly in state...

    Mingjian Lu, Min Wan, Karla F Leavens, Qingwei Chu, Bobby R Monks… in Nature Medicine (2012)