-
Article
A novel small-molecular CCR5 antagonist promotes neural repair after stroke
Chemokine receptor 5 (CCR5) is one of the main co-receptors of HIV-1, and has been found to be a potential therapeutic target for stroke. Maraviroc is a classic CCR5 antagonist, which is undergoing clinical tr...
-
Article
Open AccessA breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke
Ischemic stroke is characterized by the presence of reactive microglia. However, its precise involvement in stroke etiology is still unknown. We used metabolic profiling and showed that chemokine like factor 1...
-
Article
The Role of AMPARs Composition and Trafficking in Synaptic Plasticity and Diseases
AMPA receptors are tetrameric ionic glutamate receptors, which mediate 90% fast excitatory synaptic transmission induced by excitatory glutamate in the mammalian central nervous system through the activation o...
-
Article
Research on the optimization mechanism of loading path in hydroforming process
In this paper, the optimization mechanism of loading path in hydroforming process is researched. Firstly, the geometric model of an X-shaped tube is established by using 3D drawing software UG; the DYNAFORM so...