14 Result(s)
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Qing Dai
Cell Biology
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Article
Open AccessRBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
N6-methyladenosine (m6A) methylation can be deposited on chromatin-associated RNAs (caRNAs) by the RNA methyltransferase complex (MTC) to regulate chromatin state and transcription. However, the mechanism by whic...
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Open AccessVitamin D receptor attenuate ischemia-reperfusion kidney injury via inhibiting ATF4
Activating transcription factor 4 (ATF4) is one of the key effectors of endoplasmic reticulum stress (ERS), ATF4/CHOP pathway-mediated ERS plays an important role in the progression of acute kidney disease (AK...
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Open AccessSerotonin acts through YAP to promote cell proliferation: mechanism and implication in colorectal cancer progression
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a key messenger that mediates several central and peripheral functions in the human body. Emerging evidence indicates that serotonin is critical in tumor...
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ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing
Members of the mammalian AlkB family are known to mediate nucleic acid demethylation1,2. ALKBH7, a mammalian AlkB homologue, localizes in mitochondria and affects metabolism3, but its function and mechanism of ac...
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Open AccessComparison of nonhuman primates identified the suitable model for COVID-19
Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains challenging. Here, we characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in three NHP species: Ol...
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A metabolic labeling method detects m6A transcriptome-wide at single base resolution
Transcriptome-wide map** of N6-methyladenosine (m6A) at base resolution remains an issue, impeding our understanding of m6A roles at the nucleotide level. Here, we report a metabolic labeling method to detect m...
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Publisher Correction: N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
In the version of this article originally published, the references were incorrectly re-ordered during production. The hyphen in “N6-methyladenosine” in the title was also superscript. The errors have been correc...
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N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
N6-Methyladenosine (m6A) RNA modification is present in messenger RNAs (mRNA), ribosomal RNAs (rRNA), and spliceosomal RNAs (snRNA) in humans. Although mRNA m6A modifications have been extensively studied and sho...
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Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis
N6-methyladenosine (m6A) is the most common internal modification in eukaryotic mRNA. It is dynamically installed and removed, and acts as a new layer of mRNA metabolism, regulating biological processes including...
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A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Certain adenosine residues within mammalian RNAs undergo reversible N6 methylation. Two methyltransferase enzymes, METTL3 and METTL14, as well as the splicing factor WTAP are identified as core components of the ...
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Correction: Corrigendum: N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Nat. Chem. Biol. 7, 885–887 (2011); published online 16 October 2011; corrected after print 3 July 2012 In the version of this article initially published, one of the institute affiliations of co–first author ...
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Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA
X-ray crystallographic analysis of thymine DNA glycosylase (TDG) in complex with DNA containing 5-carboxylcytosine (5caC) analogs reveals that 5caC is a preferred substrate of TDG, providing support for a 5-me...
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Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development
One of the recent advances in the epigenetic field is the demonstration that the Tet family of proteins are capable of catalyzing conversion of 5-methylcytosine (5mC) of DNA to 5-hydroxymethylcytosine (5hmC). ...
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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
N6-Methyladenosine is an abundant nucleoside in cellular mRNA that undergoes demethylation under physiological conditions by fat mass and obesity-associated protein (FTO). This new pathway suggests that RNA mod.....
