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Scaling biological discovery at the interface of deep learning and cellular imaging

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  1. Article

    Open Access

    Iron-related gene mutations driving global Mycobacterium tuberculosis transmission revealed by whole-genome sequencing

    Iron plays a crucial role in the growth of Mycobacterium tuberculosis (M. tuberculosis). However, the precise regulatory mechanism governing this system requires further elucidation. Additionally, limited studies...

    Yameng Li, Yifan Li, Yao Liu, **anglong Kong, Ningning Tao, Yawei Hou in BMC Genomics (2024)

  2. Article

    Open Access

    Correction: Association between two-component systems gene mutation and Mycobacterium tuberculosis transmission revealed by whole genome sequencing

    Yameng Li, **anglong Kong, Yifan Li, Ningning Tao, Yawei Hou, Tingting Wang in BMC Genomics (2024)

  3. Article

    Open Access

    Single-cell and transcriptomic analyses reveal the influence of diabetes on ovarian cancer

    There has been a significant surge in the global prevalence of diabetes mellitus (DM), which increases the susceptibility of individuals to ovarian cancer (OC). However, the relationship between DM and OC rema...

    Zhihao Zhao, Qilin Wang, Fang Zhao, Junnan Ma, Xue Sui, Hyok Chol Choe in BMC Genomics (2024)

  4. Article

    Open Access

    Association between two-component systems gene mutation and Mycobacterium tuberculosis transmission revealed by whole genome sequencing

    Two-component systems (TCSs) play a crucial role in the growth of Mycobacterium tuberculosis (M. tuberculosis). However, the precise regulatory mechanism of their contribution remain to be elucidated, and only a ...

    Yameng Li, **anglong Kong, Yifan Li, Ningning Tao, Yawei Hou, Tingting Wang in BMC Genomics (2023)

  5. Article

    Open Access

    The different subtelomeric structure among 1RS arms in wheat-rye 1BL.1RS translocations affecting their meiotic recombination and inducing their structural variation

    The 1RS arm of wheat-rye 1BL.1RS translocations contains several subtelomeric tandem repeat families. To study the effect of the difference in the composition of these tandem repeats on the meiotic recombinati...

    Ziying **ong, Jie Luo, Yang Zou, Qilin Tang, Shulan Fu, Zongxiang Tang in BMC Genomics (2023)

  6. Article

    Open Access

    Integrated single-molecule real-time sequencing and RNA sequencing reveal the molecular mechanisms of salt tolerance in a novel synthesized polyploid genetic bridge between maize and its wild relatives

    Tripsacum dactyloides (2n = 4x = 72) and Zea perennis (2n = 4x = 40) are tertiary gene pools of Zea mays L. and exhibit many abiotic adaptations absent in modern maize, especially salt tolerance. A previously rep...

    **aofeng Li, **ngyu Wang, Qiangqiang Ma, Yunfeng Zhong, Yibo Zhang in BMC Genomics (2023)

  7. Article

    Open Access

    Correction: Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease

    Qian Zhu, Min Qin, Zixian Wang, Yonglin Wu, ** Chen, Chen Liu in Cell & Bioscience (2022)

  8. Article

    Open Access

    Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease

    Coronary artery disease (CAD) is a metabolically perturbed pathological condition. However, the knowledge of metabolic signatures on outcomes of CAD and their potential causal effects and impacts on left ventr...

    Qian Zhu, Min Qin, Zixian Wang, Yonglin Wu, ** Chen, Chen Liu in Cell & Bioscience (2022)

  9. Article

    Open Access

    Sequencing and characterization of the transcriptome of half-smooth tongue sole (Cynoglossus semilaevis)

    Half-smooth tongue sole (Cynoglossus semilaevis) is a valuable fish for aquaculture in China. This fish exhibits sexual dimorphism, particularly different growth rates and body sizes between two genders. Thus, C....

    Wenji Wang, Qilin Yi, Liman Ma, **aosu Zhou, Haitao Zhao, Xubo Wang, Jie Qi in BMC Genomics (2014)

  10. Article

    Open Access

    Histoplasma capsulatum proteome response to decreased iron availability

    A fundamental pathogenic feature of the fungus Histoplasma capsulatum is its ability to evade innate and adaptive immune defenses. Once ingested by macrophages the organism is faced with several hostile environme...

    Michael S Winters, Daniel S Spellman, Qilin Chan, Francisco J Gomez in Proteome Science (2008)