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  1. No Access

    Article

    The function of steroid terminal monooxygenase in cholesterol or phytosterol degradation by the Mycobacterium neoaurum NRRL B-3805

    Cholesterol and phytosterols can be served as the substrates for Actinobacteria to produce the precursors used in the synthesis of steroidal medicines. Cytochrome P450s from CYP125 and CYP142 families initiates t...

    Xuemei Li, Rui Zhang, Jianjiong Li… in Systems Microbiology and Biomanufacturing (2023)

  2. No Access

    Article

    Characterization of new recombinant 3-ketosteroid-Δ1-dehydrogenases for the biotransformation of steroids

    3-Ketosteroid-Δ1-dehydrogenases (KstDs [EC 1.3.99.4]) catalyze the Δ1-dehydrogenation of steroids and are a class of important enzymes for steroid biotransformations. In this study, we cloned 12 putative KstD-enc...

    **aojun Wang, **hui Feng, Dalong Zhang… in Applied Microbiology and Biotechnology (2017)

  3. No Access

    Article

    Characterization of (R)-selective amine transaminases identified by in silico motif sequence blast

    Compared to (S)-selective amine transaminase ((S)-AT), the (R)-selective counterpart ((R)-AT) has been less studied. As such, a simplified “Motif Sequence Blast” search (Höhne et al. Nat Chem Biol 6:807–813, 2010

    **ju Jiang, ** Chen, Dalong Zhang, Qiaqing Wu… in Applied Microbiology and Biotechnology (2015)

  4. No Access

    Article

    Engineering a hydroxysteroid dehydrogenase to improve its soluble expression for the asymmetric reduction of cortisone to 11β-hydrocortisone

    11β-Hydrocortisone (11β-HC) is an important anti-inflammatory drug and intermediate for the synthesis of other steroids. One of the methods for the synthesis of 11β-HC is the asymmetric reduction of cortisone ...

    Dalong Zhang, Rui Zhang, Jie Zhang, Liying Chen… in Applied Microbiology and Biotechnology (2014)

  5. No Access

    Article

    Substrate profiling of cyclohexylamine oxidase and its mutants reveals new biocatalytic potential in deracemization of racemic amines

    A cyclohexylamine oxidase (CHAO) of bacterial origin was previously shown to be a potentially useful catalyst in the deracemization of racemic primary amines. To further explore the properties and application ...

    Guangyue Li, Jie Ren, Hiroaki Iwaki, Dalong Zhang… in Applied Microbiology and Biotechnology (2014)

  6. No Access

    Article

    Isolation and characterization of a novel Rhodococcus strain with switchable carbonyl reductase and para-acetylphenol hydroxylase activities

    In the search for an effective biocatalyst for the reduction of acetophenones with unprotected hydroxy group on the benzene ring, a microorganism, which reduced para-acetylphenol to S-(−)-1-(para-hydroxyphenyl)et...

    Rui Zhang, Jie Ren, Yu Wang, Qiaqing Wu… in Journal of Industrial Microbiology & Biote… (2013)