11 Result(s)
within
Qiao Wu
Cell Biology
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Article
Open AccessMannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P
Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear. Here, we demonstrate that mannose, a hexos...
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Article
Open AccessZNF655 accelerates progression of pancreatic cancer by promoting the binding of E2F1 and CDK1
Pancreatic cancer has an extremely terrible prognosis and is a common cause of cancer death. In this study, the clinic value, biological function and underlying mechanisms of Zinc finger protein 655 (ZNF655) i...
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Open AccessThe metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8
Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among which the function of GSDMC has not been clearly described. Herein, we demonstrate that the metabolite α-ketoglutarate (...
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Open AccessNur77-activated lncRNA WFDC21P attenuates hepatocarcinogenesis via modulating glycolysis
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. Orphan nuclear receptor Nur77, which is low expressed in HCC, functions as a tumor suppressor to suppress HCC....
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Open AccessTom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis
Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS) and to participate in different modes of cell death, such as ferroptosis, apoptosis and necroptosis. However, whether ...
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Article
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
The orphan nuclear receptor Nur77 blocks inflammation through inhibition of p65 DNA binding and is suppressed by p38α-mediated phosphorylation. A small-molecule compound, PDNPA, disrupts p38α-Nur77 interaction...
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Article
Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway
TR3 is an orphan nuclear receptor with roles in apoptosis. A TR3-binding compound induces mitochondrial translocation of TR3 and autophagy via the Nix–Toms–ANT1/VDAC1 pathway, providing a mechanism for cell de...
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The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
A small molecule that disrupts interaction between Nur77 and LKB1 leads to LKB1 exit from the nucleus to activate cytoplasmic AMPK and, ultimately, reduces blood glucose and insulin in diabetic mice. ...
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Cytosporone B is an agonist for nuclear orphan receptor Nur77
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Article
A novel function of p53 in TR3-MDM2 cross-talk
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Article
The role of Akt on Arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation
The present study investigates the molecular details of how arsenic trioxide inhibits preadipocyte differentiation and examines the role of Akt/PKB in regulation of differentiation and apoptosis. Continual exp...
