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  1. No Access

    Article

    Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation

    The orphan nuclear receptor Nur77 blocks inflammation through inhibition of p65 DNA binding and is suppressed by p38α-mediated phosphorylation. A small-molecule compound, PDNPA, disrupts p38α-Nur77 interaction...

    Li Li, Yuan Liu, Hang-zi Chen, Feng-wei Li, Jian-feng Wu… in Nature Chemical Biology (2015)

  2. No Access

    Article

    Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

    TR3 is an orphan nuclear receptor with roles in apoptosis. A TR3-binding compound induces mitochondrial translocation of TR3 and autophagy via the Nix–Toms–ANT1/VDAC1 pathway, providing a mechanism for cell de...

    Wei-jia Wang, Yuan Wang, Hang-zi Chen, Yong-zhen **ng… in Nature Chemical Biology (2014)

  3. No Access

    Article

    The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK

    A small molecule that disrupts interaction between Nur77 and LKB1 leads to LKB1 exit from the nucleus to activate cytoplasmic AMPK and, ultimately, reduces blood glucose and insulin in diabetic mice. ...

    Yan-yan Zhan, Yan Chen, Qian Zhang, Jia-jia Zhuang, Min Tian… in Nature Chemical Biology (2012)

  4. No Access

    Article

    Cytosporone B is an agonist for nuclear orphan receptor Nur77

    Yanyan Zhan, Hangzi Chen, **g**g Liu, Bixing Zhao… in Nature Chemical Biology (2008)