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Article
FEZF2 inhibits the growth of triple-negative breast cancer cells through EZH2/PD-L1 and enhances anti-tumor immunity in vivo
Triple-negative breast cancer (TNBC) is characterized by high aggressiveness, heterogeneity, and poor prognosis. Programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors, a crucial type of i...
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Article
Open AccessDataset on the effects of psychological care on depression and suicide ideation in underrepresented children
Massive increases in the risks of depressive disorders and the ensuing suicide have become the overarching menace for children/adolescents. Despite global consensus to instigate psychological healthcare policy...
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Article
Open AccessAptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential anti pan-coronavirus activity
Emerging and recurrent infectious diseases caused by human coronaviruses (HCoVs) continue to pose a significant threat to global public health security. In light of this ongoing threat, the development of a br...
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Article
Open AccessMulti-omics analysis reveals overactive inflammation and dysregulated metabolism in severe community-acquired pneumonia patients
Severe community-acquired pneumonia (S-CAP) is a public health threat, making it essential to identify novel biomarkers and investigate the underlying mechanisms of disease severity.
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Article
Construction and evaluation of a phospholipid-based phase transition in situ gel system for brexpiprazole
The objective of this study was to develop phospholipid-based injectable phase transition in situ gels (PTIGs) for the sustained release of Brexpiprazole (Brex). Phospholipid (Lipoid S100, S100) and stearic ac...
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Article
Open AccessIdentification of a Novel Cuproptosis-Related Gene Signature in Eutopic Endometrium of Women with Endometriosis
Endometriosis (EMs) is a life-long endocrine disorder and a common cause for female infertility and pelvic pain. The key characteristics of eutopic endometrium of EMs patients are high proliferative and migrat...
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Article
Surface Functionalization of Piperine-Loaded Liposomes with Sophorolipids Improves Drug Loading and Stability
The application of amphiphilic biosurfactants in drug delivery systems has sparked interest in recent years. In this study, piperine-loaded liposomes were modified with the biosurfactant sophorolipids to bette...
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Article
Liraglutide inhibits AngII-induced cardiac fibroblast proliferation and ECM deposition through regulating miR-21/PTEN/PI3K pathway
Cardiac fibrosis characterized with the aberrant proliferation of cardiac fibroblasts and extracellular matrix (ECM) deposition is a major pathophysiological feature of atrial fibrillation (AF). Liraglutide ha...
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Article
Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics
T cells play a determining role in the immunomodulation and prognostic evaluation of cancer treatments relying on immune activation. While specific biomarkers determine the population and distribution of T cel...
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Article
Highly stable aqueous zinc-ion batteries enabled by suppressing the dendrite and by-product formation in multifunctional Al3+ electrolyte additive
Rechargeable aqueous zinc-ion batteries (ZIBs) have gained extensive attention owing to the high safety, low cost, and high power/energy densities. But unfortunately the ZIBs universally suffer from the highly...
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Article
Open AccessGSDMD enhances cisplatin-induced apoptosis by promoting the phosphorylation of eIF2α and activating the ER-stress response
GSDMD is the key effector of pyroptosis, but its non-pyroptosis-related functions have seldom been reported. Here, we report that GSDMD is overexpressed in different types of tumours, including head and neck s...
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Article
Open AccessNifuroxazide ameliorates pulmonary fibrosis by blocking myofibroblast genesis: a drug repurposing study
Idiopathic pulmonary fibrosis (IPF) is a serious interstitial lung disease with a complex pathogenesis and high mortality. The development of new drugs is time-consuming and laborious; therefore, research on t...
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Article
Different Changing Patterns of Three NOS–NO System Activities after Ischemia–Reperfusion in Rabbit with AMI
NOS–NO system activity is closely correlated with ischemia–reperfusion injury (IRI) and NOS subtypes were suggested to play different roles in IRI. In this work, the activity of serum NOS, NO levels, and ische...
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Article
Open AccessSmooth muscle-derived macrophage-like cells contribute to multiple cell lineages in the atherosclerotic plaque
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Article
Open AccessGenetic fate-map** reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury
During injury, monocytes are recruited from the circulation to inflamed tissues and differentiate locally into mature macrophages, with prior reports showing that cavity macrophages of the peritoneum and peric...
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Article
Open AccessAquaporin 3 promotes human extravillous trophoblast migration and invasion
Does aquaporin 3 (AQP3) affect the migration and invasion of human extravillous trophoblast (HTR8/Svneo) cells?
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Chapter and Conference Paper
Application of Four-Chain Integration Theory on Cultural Derivative Design — A Case Study of Shanghai History Museum
The development of society, the increase of people's income and other factors have driven the upgrading of tourism consumption.In recent years, with the rapid development of social new media, there are more an...
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Chapter and Conference Paper
Architecture Design of Intangible Cultural Heritage Games Based on WeChat Mini Programs - Chongming Biandan Opera as an Example
As an important part of Shanghai's intangible cultural heritage, Chongming Biandan Opera has high inheritance value. With the emergence of interesting and interactive cultural communication methods, the dissem...
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Chapter and Conference Paper
A Case Study of Social Innovation Based on Ten Years' Practice-Taking the Project of “Design for Country” in Shanghai as an Example
In the current competitive environment, design no longer serves scale competition, but serves innovation competition. If a city wants to build an innovative city, it must carry out industrial transformation. i...
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Article
Open AccessResearch on aircraft route planning optimization problem with multi-constraints and dual-targets
As the core technology in the field of aircraft, the route planning has attracted much attention. However, due to the complexity of the structure and performance constraints of the aircraft, the route planning...
