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Article
Quick assembly of 1-alkylidenyl-tetrahydroisoquinolines via a Catellani reaction/NBS-mediated cyclization sequence and synthetic applications
We herein disclose a modular synthesis of 1-bromomethylene-THIQs involving a Catellani reaction of aryl iodides, aziridines, and terminal alkynes followed by an N-bromosuccinimide (NBS)-mediated cyclization. This...
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Article
Chemoenzymatic synthesis of C14-functionalized steroids
C14-functionalized steroids display biological activity and have been used as medicines. The lack of synthetic methods to access C14-functionalized steroids has, however, impeded steroidal drug discovery. In t...
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Article
Synthesis of planar chiral ferrocenes via enantioselective remote C–H activation
Planar chiral ferrocenes are widely studied structures in asymmetric catalysis, materials science and medicinal chemistry. Although synthetic methods for 1,2-disubstituted planar chiral ferrocenes are well kno...
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Article
Open AccessDiversity-oriented functionalization of 2-pyridones and uracils
Heterocycles 2-pyridone and uracil are privileged pharmacophores. Diversity-oriented synthesis of their derivatives is in urgent need in medicinal chemistry. Herein, we report a palladium/norbornene cooperativ...
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Article
Construction of axial chirality via palladium/chiral norbornene cooperative catalysis
Axially chiral biaryls are common structural motifs in functional materials, bioactive natural products, pharmaceuticals and chiral catalysts/ligands. As such, efficient preparation of these privileged scaffol...
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Article
Precise Functionalization of Remote C-H Bonds
Remote C-H bond functionalization of arenes with precise control is a recognized extraordinary challenge in organic synthesis. Recently, Yu and Houk et al. developed an elegant strategy to distinguish and functio...
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Article
Open AccessA biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids
Steroidal C19-hydroxylation is pivotal to the synthesis of naturally occurring bioactive C19-OH steroids and 19-norsteroidal pharmaceuticals. However, realizing this transformation is proved to be challenging ...
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Article
Leader-Following Consensus of Multi-Agent Systems via Adaptive Event-Based Control
In this paper, the adaptive event-based control approach is applied to study leader-following consensus of multi-agent systems with linear dynamic models. Adaptive event-based controller and triggering functio...
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Article
Fully distributed consensus of second-order multi-agent systems using adaptive event-based control
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Article
Adaptive Event-Based Consensus of Multi-Agent Systems with General Linear Dynamics
In this paper, adaptive event-based consensus of multi-agent systems with general linear dynamics is considered. A novel adaptive event-based controller and a state-dependent triggering function are proposed f...