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Article
Open AccessFoxO gene family evolution in vertebrates
Forkhead box, class O (FoxO) belongs to the large family of forkhead transcription factors that are characterized by a conserved forkhead box DNA-binding domain. To date, the FoxO group has four mammalian memb...
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Article
Open AccessA cross-study gene set enrichment analysis identifies critical pathways in endometriosis
Endometriosis is an enigmatic disease. Gene expression profiling of endometriosis has been used in several studies, but few studies went further to classify subtypes of endometriosis based on expression patter...
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Article
Open AccessRegression-based approach for testing the association between multi-region haplotype configuration and complex trait
It is quite common that the genetic architecture of complex traits involves many genes and their interactions. Therefore, dealing with multiple unlinked genomic regions simultaneously is desirable.
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Article
Open AccessA comparative genome analysis of gene expression reveals different regulatory mechanisms between mouse and human embryo pre-implantation development
Pre-implantation development is a crucial step in successful implantation and pregnancy in mammals. It has been studied in depth, but mostly in laboratory animal models. Less is known about the regulatory mech...
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Article
Comparative analysis of vertebrate PEPT1 and PEPT2 genes
The plasma membrane transport proteins belong to SoLute Carrier 15 (SLC15) family and two members of this family have been characterized extensively in higher vertebrates, namely PEPT1 and PEPT2. Despite many ...
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Article
Comparative analysis of MTF-1 binding sites between human and mouse
MTF-1 is a crucial transcription factor involved in the cellular response to heavy-metal load and other stresses by specifically binding to metal response elements (MREs). Thus far only a handful of direct tar...
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Article
Open AccessReCGiP, a database of reproduction candidate genes in pigs based on bibliomics
Reproduction in pigs is one of the most economically important traits. To improve the reproductive performances, numerous studies have focused on the identification of candidate genes. However, it is hard for ...
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Article
Mitochondrial DNA-Based Genetic Structure Analysis of Pudong White Pigs
There are extensive debates concerning the origin and the necessity of conservation of Pudong White pigs in the Taihu region of China. To elucidate their genetic ancestry, we sequenced the complete mtDNA D-loo...
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Article
Molecular selection and functional divergence of HIF-α proteins in vertebrates
HIF-α transcription factors, as key master regulators of oxygen homeostasis, constitute a subgroup of the large bHLH-PAS transcription factor family and have been identified in many vertebrates. Although the a...
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Article
Application of multivariate statistical techniques in the assessment of water quality in the Southwest New Territories and Kowloon, Hong Kong
The application of different multivariate statistical techniques for the interpretation of a complex data matrix obtained during 2000–2007 from the watercourses in the Southwest New Territories and Kowloon, Ho...
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Article
Uncovering the transcriptional circuitry in skeletal muscle regeneration
Skeletal muscle has a remarkable ability to regenerate after repeated and complete destruction of the tissue. The healing phases for an injured muscle undergo an activation program controlled by a dynamically ...
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Article
WRKY gene family evolution in Arabidopsis thaliana
The Arabidopsis thaliana WRKY proteins are characterized by a sequence of 60 amino acids including WRKY domain. It is well established that these proteins are involved in the regulation of various physiological p...
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Article
Comparative gene expression analysis in mouse models for identifying critical pathways in mammary gland development
Functional development of the mammary gland is an important physiological process. Several studies have used gene expression profiling of mammary gland development to identify the key genes in the process, but...
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Article
Open AccessThe prediction of the porcine pre-microRNAs in genome-wide based on support vector machine (SVM) and homology searching
MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression by targeting mRNAs for translation repression or mRNA degradation. Although many miRNAs have been discovered and studied in...
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Article
Open AccessComparative study of the promotion of porcine fetal fibroblast proliferation by overexpression of two transcriptional variants of SIRT6
Mammalian Sirtuin 6 (SIRT6) plays an important role in the transcriptional silencing of silent mating-type loci, telomeres, and rDNA. However, the roles of porcine SIRT6 in cell proliferation are poorly understoo...
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Article
Association study between gene polymorphisms in PPAR signaling pathway and porcine meat quality traits
There is increasing evidence suggesting that fatty acids biosynthesis and metabolism are regulated by peroxisome proliferator-activated receptors (PPARs), mostly through the PPAR signaling pathway at the trans...
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Article
The yellow-fruited tomato 1 (yft1) mutant has altered fruit carotenoid accumulation and reduced ethylene production as a result of a genetic lesion in ETHYLENE INSENSITIVE2
The isolated yft1 allele controls the formation of fruit color in n3122 via the regulation of response to ethylene, carot...
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Article
Application of partial least squares in exploring the genome selection signatures between populations
Natural and artificial selection have led to substantial variation in the phenotypic traits of different populations. Therefore, there is a need to develop methods that are based on cross-population comparison...
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Article
Inflammation suppression by dexamethasone via inhibition of CD147-mediated NF-κB pathway in collagen-induced arthritis rats
Dexamethasone (Dex) exhibits broad-spectrum anti-inflammatory effects in chronic destructive rheumatoid arthritis. We present in vivo and in vitro evidence supporting the preventive effects and underlying mech...
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Article
A simplest Lorenz-like chaotic circuit and its applications in secure communication and weak signal detection
This paper is devoted to introduce a simplest Lorenz-like chaotic circuit and the calculation of Hamiltonian energy function for the corresponding dimensionless Lorenz-like chaotic system, as well as its appli...
