10,371 Result(s)

Article

The autoregulation of insulin secretion in the isolated pancreatic islets of lean (obOb) and obese-hyperglycemic (obob) mice

The autoregulation of insulin secretion was studied using perifused and incubated pancreatic islets of normal (obOb) mice and of their obese-hyperglycemic (obob) littermates. Islets secreted more insulin when ...

L. Loreti, J. C. Dunbar, S. Chen, P. P. Foà in Diabetologia (1974)

Article

Implantable artificial capillary unit for pancreatic islet allograft and xenograft

Implantable artificial capillary units containing approximately 1,200 allogeneic rat islets, or approximately 3,000 xenogeneic rabbit or human islets as an implantable artificial endocrine pancreas (IAEP) were...

Dr. W. J. Tze, F. C. Wong, L. M. Chen in Diabetologia (1979)

Article

Are the binding and degradation of low density lipoprotein altered in type 2 (non-insulin-dependent) diabetes mellitus?

Studies in vitro have shown that glycosylation of low density lipoprotein (LDL) will decrease its ability to bind to its receptor. We have evaluated the possibility that such an event might occur in vivo in di...

F. B. Kraemer, Y. -D. I. Chen, R. M. C. Cheung, G. M. Reaven in Diabetologia (1982)

Article

Insulin suppression of plasma-free fatty acid concentration in normal individuals and patients with Type 2 (non-insulin-dependent) diabetes

In order to define the effect of Type 2 (non-insulin-dependent) diabetes mellitus on the ability of insulin to regulate plasma-free fatty acid (FFA) concentrations, we determined the plasma FFA response to the...

A. L. M. Swislocki, Y. -D. I. Chen, A. Golay, M. -O. Chang, M. Reaven in Diabetologia (1987)

Article

Relationship between glucose tolerance, insulin secretion, and insulin action in non-obese individuals with varying degrees of glucose tolerance

Plasma glucose and insulin concentration following a 75 g oral glucose challenge and glucose uptake during a hyperinsulinaemic glucose clamp study were determined in 50 non-obese individuals. The study populat...

G. M. Reaven, C. B. Hollenbeck, Y. -D. I. Chen in Diabetologia (1989)

Article

Beta-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats

Glucose-induced insulin secretion is impaired in the presence of chronic hyperglycaemia. Insulin secretion was studied in a diabetic rat model prior to the beta cells becoming non-responsive to glucose in orde...

J. L. Leahy, L. M. Bumbalo, C. Chen in Diabetologia (1993)

Article

Seventeenth Sir Peter Freyer memorial lecture and surgical symposium

E. O’Broin, J. Donohoe, K. Mealy, M. Kerin, P. Gillen… in Irish Journal of Medical Science (1994)

Article

Evaluation of octreotide to assess insulin-mediated glucose disposal by the insulin suppression test

D. Pei, C. N. O. Jones, R. Bhargava, Y. -D. I. Chen, G. M. Reaven MD in Diabetologia (1994)

Article

Effect of glipizide treatment on postprandial lipaemia in patients with NIDDM

The primary goal of the present study was to examine the effects of improved glycaemic control associated with glipizide treatment on postprandial lipaemia in non-insulin-dependent diabetic patients. The metab...

J. Jeppesen, M. -Y. Zhou, Y. -D. I. Chen, G. M. Reaven M. D. in Diabetologia (1994)

Article

Lactate dehydrogenase-elevating virus: an ideal persistent virus?

LDV contradicts all commonly held views about mechanisms of virus persistence, namely that persistence is primarily associated with noncytopathic viruses, or the selection of immune escape variants or other mu...

Peter G. W. Plagemann, Raymond R. R. Rowland… in Springer Seminars in Immunopathology (1995)

Article

Macro-microangiopathy and endothelial dysfunction in NIDDM patients with and without diabetic nephropathy

The Steno hypothesis suggests that albuminuria reflects widespread vascular damage (proliferative retinopathy and severe macroangiopathy) due to a generalized vascular (endothelial) dysfunction. We assessed t...

H.-H. Parving, F. S. Nielsen, L. E. Bang, U. M. Smidt, T. L. Svendsen… in Diabetologia (1996)

Article

Relationship between insulin-mediated glucose disposal and regulation of plasma and adipose tissue lipoprotein lipase

The relationship between insulin-mediated glucose disposal and fasting insulin and triglyceride (TG) concentrations, plasma post-heparin lipoprotein lipase (PH-LPL) activity and mass, and adipose tissue LPL a...

P. Maheux, S. Azhar, P. A. Kern, Y.-D. I. Chen, G. M. Reaven in Diabetologia (1997)

Article

Rectal Immunization for Induction of Specific Antibody in the Genital Tract of Women

The purpose of the current study was to examine potential routes of vaccine administration for the induction of antigen-specific responses in the genital tract of women. Sixteen women were enrolled in this stu...

P. A. Crowley-Nowick, M. C. Bell, R. Brockwell… in Journal of Clinical Immunology (1997)

Article

Erratum to: Individual bioequivalence: new concepts in the statistical assessment of bioequivalence metrics

R. N. Patnaik, L. J. Lesko, M. L. Chen in Clinical Pharmacokinetics (1997)

Article

Evidence that insulin can directly inhibit hepatic glucose production

In order to evaluate the role of portal insulin in the modulation of hepatic glucose production (HGP), measurements of plasma glucose and insulin concentrations and both HGP and peripheral glucose disappearanc...

P. Maheux, Y. D. I. Chen, K. S. Polonsky, G. M. Reaven in Diabetologia (1997)

Article

How is the insulin content regulated in nondiabetic hyperinsulinaemic, insulin resistant states? Study of spontaneously hypertensive rats

Jack L. Leahy, Chuan Chen, Christopher J. Rhodes in Diabetologia (1998)

Article

Short-wavelength sensitive visual field loss in patients with clinically significant diabetic macular oedema

The aim of the study was to compare the sensitivity of short-wavelength and conventional automated static threshold perimetry for the psychophysical detection of abnormality in patients with clinically signif...

C. Hudson, J. G. Flanagan, G. S. Turner, H. C. Chen, L. B. Young, D. McLeod in Diabetologia (1998)

Article

Influence of laser photocoagulation for clinically significant diabetic macular oedema (DMO) on short-wavelength and conventional automated perimetry

The aim of the study was to determine the effect of laser photocoagulation for clinically significant diabetic macular oedema (DMO) on macular visual function as assessed by conventional and short-wavelength ...

C. Hudson, J. G. Flanagan, G. S. Turner, H. C. Chen, L. B. Young, D. McLeod in Diabetologia (1998)

Article

Visceral adipose tissue is not increased in Pima Indians compared with equally obese Caucasians and is not related to insulin action or secretion

Pima Indians are insulin resistant and hyperinsulinaemic compared with Caucasians. We investigated whether abdominal fat distribution was different between Pimas and Caucasians and whether differences in the ...

J.-F. Gautier, M. R. Milner, E. Elam, K. Chen, E. Ravussin, R. E. Pratley in Diabetologia (1999)

Article

35th Annual Meeting of the European Association for the Study of Diabetes

A. Melander, J. Olsson, G. Lindberg, A. Salzman, T. Howard, P. Stang… in Diabetologia (1999)