7 Result(s)
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English
Biomedicine, general
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Article
Pharmacological characterization of a novel metal-based proteasome inhibitor Na-AuPT for cancer treatment
The ubiquitin-proteasome system (UPS) is essential for maintaining cell homeostasis by orchestrating the protein degradation, but is impaired in various diseases, including cancers. Several proteasome inhibito...
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Article
Connecting copper and cancer: from transition metal signalling to metalloplasia
Copper is an essential nutrient whose redox properties make it both beneficial and toxic to the cell. Recent progress in studying transition metal signalling has forged new links between researchers of differe...
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Article
Open AccessThe role of ferroptosis in lung cancer
Lung cancer is one of the most common cancers in the world. Although medical treatment has made impressive progress in recent years, it is still one of the leading causes of cancer-related deaths in men and wo...
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Article
Preface
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Article
Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing
In the past 15 years, the proteasome has been validated as an anti-cancer drug target and 20S proteasome inhibitors (such as bortezomib and carfilzomib) have been approved by the FDA for the treatment of multi...
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Article
Open AccessMetal-based proteasomal deubiquitinase inhibitors as potential anticancer agents
Deubiquitinases (DUBs) play an important role in protein quality control in eukaryotic cells due to their ability to specifically remove ubiquitin from substrate proteins. Therefore, recent findings have focus...
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Article
Gene–environment interactions between JAZF1 and occupational and household lead exposure in prostate cancer among African American men
A single nucleotide polymorphism, rs10486567, in JAZF1 has consistently been associated with increased risk of prostate cancer. The physical interaction of zinc finger proteins, such as JAZF1, with heavy metals m...
