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Article
Pharmacological characterization of a novel metal-based proteasome inhibitor Na-AuPT for cancer treatment
The ubiquitin-proteasome system (UPS) is essential for maintaining cell homeostasis by orchestrating the protein degradation, but is impaired in various diseases, including cancers. Several proteasome inhibito...
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Article
Connecting copper and cancer: from transition metal signalling to metalloplasia
Copper is an essential nutrient whose redox properties make it both beneficial and toxic to the cell. Recent progress in studying transition metal signalling has forged new links between researchers of differe...
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Article
Open AccessThe role of ferroptosis in lung cancer
Lung cancer is one of the most common cancers in the world. Although medical treatment has made impressive progress in recent years, it is still one of the leading causes of cancer-related deaths in men and wo...
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Article
Open AccessRegulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30
Deubiquitinates (DUBs) have been suggested as novel promising targets for cancer therapies. Accumulating experimental evidence suggests that some metal compounds have the potential to induce cancer cell death ...
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Article
The 5-dissections of two infinite product expansions
In this paper, we establish 5-dissections of two infinite products and thereby prove that their q-series coefficients vanish for two arithmetic progressions. Moreover, our results also imply that the signs of coe...
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Reference Work Entry In depth
Deubiquitylating Enzymes
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Article
Experimental methods for determination of mechanical behaviors of materials at high temperatures via the split Hopkinson bars
Full understanding of the thermomechanical behaviors of materials at high strain rates and high temperatures are of great importance from not only scientific meaning but also practical value in engineering str...
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Living Reference Work Entry In depth
Deubiquitylating Enzymes
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Article
Open AccessProteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma
The first line therapy for patients with diffuse large B cell (DLBCL) is R-CHOP. About half of DLBCL patients are either refractory to, or will relapse, after the treatment. Therefore, identifying novel drug t...
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Article
Open AccessDisulfiram and BKM120 in Combination with Chemotherapy Impede Tumor Progression and Delay Tumor Recurrence in Tumor Initiating Cell-Rich TNBC
Tumor initiating cells (TIC) have been suggested as a mechanism for driving chemoresistance and tumor recurrence in human cancers including triple negative breast cancer (TNBC). Significant progress has been m...
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Chapter
Discovery of Green Tea Polyphenol-Based Antitumor Drugs: Mechanisms of Action and Clinical Implications
Green tea polyphenols, especially catechins, have shown great promise for use as anticancer agents. One such catechin, epigallocatechin-3 gallate (EGCG), is of particular interest due to mounting evidence of i...
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Article
Open AccessGrowth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination
It has been well known that androgen receptor (AR) is critical to prostate cancer development and progression. It has also been documented that AR is expressed in more than 60% of breast tumors, which promotes...
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Article
Preface
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Article
Parity results for 13-regular partitions and broken 6-diamond partitions
Let \(b_{13}(n)\) b ...
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Article
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need for improved cancer treatment is drug repurposing....
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Article
Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing
In the past 15 years, the proteasome has been validated as an anti-cancer drug target and 20S proteasome inhibitors (such as bortezomib and carfilzomib) have been approved by the FDA for the treatment of multi...
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Article
Open AccessMetal-based proteasomal deubiquitinase inhibitors as potential anticancer agents
Deubiquitinases (DUBs) play an important role in protein quality control in eukaryotic cells due to their ability to specifically remove ubiquitin from substrate proteins. Therefore, recent findings have focus...
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Article
New Ramanujan type congruences modulo 5 for overpartitions
Let \(\overline{p}(n)\) ...
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Article
A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy
Based on the central role of the ubiquitin–proteasome system (UPS) in the degradation of cellular proteins, proteasome inhibition has been considered an attractive approach for anticancer therapy. Deubiquitina...
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Article
Congruences for (3,11)-regular bipartitions modulo 11
In this note we investigate the function \(B_{k,\ell }(n)\) ...