48 Result(s)

Article

Pharmacological characterization of a novel metal-based proteasome inhibitor Na-AuPT for cancer treatment

The ubiquitin-proteasome system (UPS) is essential for maintaining cell homeostasis by orchestrating the protein degradation, but is impaired in various diseases, including cancers. Several proteasome inhibito...

Da-cai Xu, Li Yang, Pei-quan Zhang, Ding Yan, Qian Xue… in Acta Pharmacologica Sinica (2022)

Article

Connecting copper and cancer: from transition metal signalling to metalloplasia

Copper is an essential nutrient whose redox properties make it both beneficial and toxic to the cell. Recent progress in studying transition metal signalling has forged new links between researchers of differe...

Eva J. Ge, Ashley I. Bush, Angela Casini, Paul A. Cobine… in Nature Reviews Cancer (2022)

Article

The 5-dissections of two infinite product expansions

In this paper, we establish 5-dissections of two infinite products and thereby prove that their q-series coefficients vanish for two arithmetic progressions. Moreover, our results also imply that the signs of coe...

Donna Q. J. Dou, Jiejuan **ao in The Ramanujan Journal (2021)

Reference Work Entry In depth

Deubiquitylating Enzymes

**n Li, Q. ** Dou in Encyclopedia of Molecular Pharmacology (2021)

Article

Experimental methods for determination of mechanical behaviors of materials at high temperatures via the split Hopkinson bars

Full understanding of the thermomechanical behaviors of materials at high strain rates and high temperatures are of great importance from not only scientific meaning but also practical value in engineering str...

Q. B. Dou, K. R. Wu, T. Suo, C. Zhang, X. Guo, Y. Z. Guo… in Acta Mechanica Sinica (2020)

Chapter

Discovery of Green Tea Polyphenol-Based Antitumor Drugs: Mechanisms of Action and Clinical Implications

Green tea polyphenols, especially catechins, have shown great promise for use as anticancer agents. One such catechin, epigallocatechin-3 gallate (EGCG), is of particular interest due to mounting evidence of i...

Reda Saber Ibrahim Ahmed, Claire Soave, Tracey Guerin Edbauer… in Medicinal Plants (2019)

Article

Preface

Q. ** Dou in Cancer and Metastasis Reviews (2017)

Article

Parity results for 13-regular partitions and broken 6-diamond partitions

Let \(b_{13}(n)\) b ...

Donna Q. J. Dou, Litao Guo, Bernard L. S. Lin in The Ramanujan Journal (2017)

Article

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need for improved cancer treatment is drug repurposing....

Zdenek Skrott, Martin Mistrik, Klaus Kaae Andersen, Søren Friis, Dusana Majera… in Nature (2017)

Article

Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing

In the past 15 years, the proteasome has been validated as an anti-cancer drug target and 20S proteasome inhibitors (such as bortezomib and carfilzomib) have been approved by the FDA for the treatment of multi...

Claire L. Soave, Tracey Guerin, **bao Liu, Q. ** Dou in Cancer and Metastasis Reviews (2017)

Article

New Ramanujan type congruences modulo 5 for overpartitions

Let \(\overline{p}(n)\) ...

Donna Q. J. Dou, Bernard L. S. Lin in The Ramanujan Journal (2017)

Article

A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy

Based on the central role of the ubiquitin–proteasome system (UPS) in the degradation of cellular proteins, proteasome inhibition has been considered an attractive approach for anticancer therapy. Deubiquitina...

C Zhao, X Chen, D Zang, X Lan, S Liao, C Yang, P Zhang, J Wu, X Li, N Liu… in Oncogene (2016)

Article

Congruences for (3,11)-regular bipartitions modulo 11

In this note we investigate the function \(B_{k,\ell }(n)\) ...

Donna Q. J. Dou in The Ramanujan Journal (2016)