7 Result(s)
within
Pu-Ste Liu
Immunology
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Article
Open AccessFunctional polarization of tumor-associated macrophages dictated by metabolic reprogramming
Macrophages are highly plastic in different tissues and can differentiate into functional subpopulations under different stimuli. Tumor-associated macrophages (TAMs) are one of the most important innate immune...
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Article
Open AccessAuthor Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions
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Article
Open AccessCD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions
Exposure of lipopolysaccharide triggers macrophage pro-inflammatory polarization accompanied by metabolic reprogramming, characterized by elevated aerobic glycolysis and a broken tricarboxylic acid cycle. Howe...
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Article
PERK is a critical metabolic hub for immunosuppressive function in macrophages
Chronic inflammation triggers compensatory immunosuppression to stop inflammation and minimize tissue damage. Studies have demonstrated that endoplasmic reticulum (ER) stress augments the suppressive phenotype...
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Article
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
The metabolic challenges present in tumors attenuate the metabolic fitness and antitumor activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether persistent metabolic insufficie...
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Article
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
How glutamine metabolism orchestrates macrophage activation is unclear. Ho and colleagues show glutamine metabolism tailors the immune responses of macrophages through metabolic and epigenetic reprogramming.
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Article
Open AccessMetabolic communication in tumors: a new layer of immunoregulation for immune evasion
The success of cancer immunotherapy reveals the power of host immunity on killing cancer cells and the feasibility to unleash restraints of anti-tumor immunity. However, the immunosuppressive tumor microenviro...
