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  1. No Access

    Article

    Targeting TBK1 to overcome resistance to cancer immunotherapy

    Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment strategies to overcome resistance to cancer immunotherapy are lacking1,2. Here we identify the innate immune kinase TANK-bin...

    Yi Sun, Or-yam Revach, Seth Anderson, Emily A. Kessler, Clara H. Wolfe… in Nature (2023)

  2. Article

    Open Access

    Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial

    While BRAF inhibitor combinations with EGFR and/or MEK inhibitors have improved clinical efficacy in BRAFV600E colorectal cancer (CRC), response rates remain low and lack durability. Preclinical data suggest that...

    Jun Tian, Jonathan H. Chen, Sherry X. Chao, Karin Pelka… in Nature Medicine (2023)

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  3. No Access

    Article

    3D human nonalcoholic hepatic steatosis and fibrosis models

    This study presents a simple and robust three-dimensional human hepatic tissue model to emulate steatotic and fibrotic conditions and provide an in vitro model for drug testing and mechanistic studies. Using a...

    Sushila Maharjan, Diana Bonilla, Princy Sindurakar… in Bio-Design and Manufacturing (2021)