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Article
Open AccessDNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1...
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Article
Open AccessEvaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies
A large number of analysis strategies are available for DNA methylation (DNAm) array and RNA-seq datasets, but it is unclear which strategies are best to use. We compare commonly used strategies and report how...
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Article
Open AccessAn integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis
Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation...
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Article
Open AccessDifferentially methylated regions in T cells identify kidney transplant patients at risk for de novo skin cancer
Cutaneous squamous cell carcinoma (cSCC) occurs 65–200 times more in immunosuppressed organ transplant patients than in the general population. T cells, which are targeted by the given immunosuppressive drugs,...
