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Article
Open AccessNKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcoma
Leiomyosarcoma (LMS), the most common soft tissue sarcoma, exhibits heterogeneous and complex genetic karyotypes with severe chromosomal instability and rearrangement and poor prognosis.
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Article
Open AccessPreventive healthcare policies in the US: solutions for disease management using Big Data Analytics
Data-driven healthcare policy discussions are gaining traction after the Covid-19 outbreak and ahead of the 2020 US presidential elections. The US has a hybrid healthcare structure; it is a system that does no...
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Chapter and Conference Paper
Understanding Flooding Detection Using Overhead Imagery - Lessons Learned
Floods are one of the most devastating and costly natural disasters, posing a significant threat to human life and property, and necessitating systematic and timely response to flood risks. While most floods c...
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Article
Open AccessCombined genetic mutations and DNA-methylated genes as biomarkers for endometrial cancer detection from cervical scra**s
Endometrial cancer is a common gynecologic cancer. Noninvasive molecular biomarkers for triage of high-risk patients for invasive procedures are needed. Based on the success of cytological Pap smear screening,...
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Article
Open AccessOvarian cancer detection by DNA methylation in cervical scra**s
Ovarian cancer (OC) is the most lethal gynecological cancer, worldwide, largely due to its vague and nonspecific early stage symptoms, resulting in most tumors being found at advanced stages. Moreover, due to ...
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Article
Open AccessPaired Box-1 (PAX1) Activates Multiple Phosphatases and Inhibits Kinase Cascades in Cervical Cancer
DNA methylation alteration, such as global hypomethylation and localized hypermethylation, within the promoters of tumor suppressor genes, is an important risk factor in cervical cancer. The potential use of D...
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Article
Open AccessTriage of high-risk human papillomavirus-positive women by methylated POU4F3
Insufficient specificity of the high-risk human papillomavirus (hrHPV) assay in primary cervical cancer screening results in unnecessary referral. Additional assays to triage hrHPV-positive women are needed to...
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Article
Open AccessConcordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm
Non-attendance at gynecological clinics is a major limitation of cervical cancer screening and self-collection of samples may improve this situation. Although HPV testing of self-collected vaginal samples is a...
