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Article
Follow-up in Fracture Liaisons Services: the involvement of general practitioners and fracture nurses is urgently needed
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Article
Open AccessDistribution of Prevalent and Incident Vertebral Fractures and Their Association with Bone Mineral Density in Postmenopausal Women in the Teriparatide Versus Risedronate VERO Clinical Trial
Vertebral fractures (VFx) occur most frequently in the mid-thoracic and thoraco-lumbar regions, which experience the highest mechanical loading along the spine. The prevalence and incidence of VFx by their loc...
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Article
Open AccessAssociation Between Nursing Support Levels and Effectiveness of Golimumab in the Management of Patients with Rheumatologic Diseases
The main objective of this study was to assess the level of nursing support received by biologic-naïve rheumatological patients treated with golimumab during their first cycle.
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Article
The role of the Fracture Liaison Service (FLS) in subsequent fracture prevention in the extreme elderly
Several guidelines recommend a bone and fall-related osteoporosis risk assessment in all patients with fracture and age > 50 years. In practice, however, there is no consensus whether screening > 85 years is u...
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Article
Serum 25-hydroxy-vitamin D and the risk of fractures in the teriparatide versus risedronate VERO clinical trial
Using data from the 2-year, randomized, double-dummy VERO trial, we examined the changes in 25-hydroxy-vitamin D (25[OH]D) concentrations over time, and whether the fracture risk reduction of teriparatide vers...
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Management of Male Osteoporosis
After middle age, osteoporosis-related fractures are more common in women than in men. As a result, fracture prevention has been most extensively studied in postmenopausal women. However, between 30% and 40% o...
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Article
Open AccessA 12-week randomized, double-blind, placebo-controlled multicenter study of choline-stabilized orthosilicic acid in patients with symptomatic knee osteoarthritis
The aim of this study was to assess the efficacy of choline-stabilized orthosilicic acid (ch-OSA) in patients with symptomatic knee osteoarthritis (OA).
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Article
Open AccessThe isotype repertoire of antibodies against novel UH-RA peptides in rheumatoid arthritis
Recently, autoantibodies against novel UH-RA peptides (UH-RA.1 and UH-RA.21) were identified as candidate biomarkers for patients with rheumatoid arthritis (RA) who are seronegative for the current diagnostic ...
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Open AccessThe prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma
An increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with ...
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Article
Open AccessPatients lacking classical poor prognostic markers might also benefit from a step-down glucocorticoid bridging scheme in early rheumatoid arthritis: week 16 results from the randomized multicenter CareRA trial
Considering a lack of efficacy data in patients with early rheumatoid arthritis (eRA) presenting without classical markers of poor prognosis, we compared methotrexate (MTX) with or without step-down glucocorti...
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Article
Open AccessFracture prevention in COPD patients; a clinical 5-step approach
Although osteoporosis and its related fractures are common in patients with COPD, patients at high risk of fracture are poorly identified, and consequently, undertreated. Since there are no fracture prevention...
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Article
High-resolution peripheral quantitative CT in rheumatology
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Article
High-resolution in vivo imaging of bone and joints: a window to microarchitecture
High-resolution peripheral quantitative CT (HR-pQCT) enables noninvasive evaluation of bones and joints by producing high-resolution 3D images with exposure to...
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Article
Remission Over 3 Years in Patients with Paget Disease of Bone Treated with a Single Intravenous Infusion of 5 mg Zoledronic Acid
Using data from the Belgian Paget’s Disease Registry of 142 patients treated with a 5 mg intravenous infusion of zoledronic acid, we examined disease remission over 3 years in 98 patients with Paget disease of...
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Article
Open AccessThe P2X7 loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels
The P2X 7 receptor plays an important role in cytokine release during the inflammatory response in vivo. Polymorphisms within the P2X 7 ...
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Open AccessThe role of RANK ligand/OPG system in bone erosions in rheumatoid arthritis
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Osteoimmunology and osteoporosis
The concept of osteoimmunology is based on growing insight into the links between the immune system and bone at the anatomical, vascular, cellular, and molecular levels. In both rheumatoid arthritis (RA) and a...
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Article
Open AccessOsteopenia: A Diagnostic and Therapeutic Challenge
We discussed whether we are able to select a subgroup of patients with osteopenia having a high fracture risk, in which anti-osteoporotic drug treatment can be advocated. We concluded that in individuals in wh...
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Article
The majority of the genetic risk for Paget’s disease of bone is explained by genetic variants close to the CSF1, OPTN, TM7SF4, and TNFRSF11A genes
Paget’s disease of bone (PDB) is one of the most frequent metabolic bone disorders (1–5%), next to osteoporosis, affecting individuals above age 55. Sequestosome1 mutations explain a part of the PDB patients, but...
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Article
The Role of Exercise in the Treatment of Osteoporosis
The objective of exercise in the treatment of osteoporosis is to improve axial stability through improvement of muscle strength. Therefore, a back extension exercise program specific to one’s musculoskeletal c...
