73 Result(s)

Article

Inhaled drug delivery: a randomized study in intubated patients with healthy lungs

The administration technique for inhaled drug delivery during invasive ventilation remains debated. This study aimed to compare in vivo and in vitro the deposition of a radiolabeled aerosol generated through f...

Jonathan Dugernier, Déborah Le Pennec, Guillaume Maerckx… in Annals of Intensive Care (2023)

Article

Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial

Findings from preclinical studies and one pilot clinical trial suggest potential benefits of epidural analgesia in acute pancreatitis. We aimed to assess the efficacy of thoracic epidural analgesia, in additio...

Matthieu Jabaudon, Alexandra Genevrier, Samir Jaber, Olivier Windisch… in Critical Care (2023)

Article

Profile of liver cholestatic biomarkers following prolonged ketamine administration in patients with COVID-19

To investigate the possible influence of prolonged ketamine (K) or esketamine (ESK) infusion on the profile of liver cholestatic biomarkers in patients with COVID-19 infection.

Julie Henrie, Ludovic Gerard, Caroline Declerfayt, Adrienne Lejeune… in BMC Anesthesiology (2023)

Article

Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors

Impact of in-ICU transfusion on long-term outcomes remains unknown. The purpose of this study was to assess in critical-care survivors the association between in-ICU red blood cells transfusion and 1-year mort...

Alice Blet, Joel B. McNeil, Julie Josse, Bernard Cholley, Raphaël Cinotti… in Critical Care (2022)

Article

Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19

SARS-CoV-2 causes major disturbances in serum metabolite levels, associated with severity of the immune response. Despite the numerous advantages of urine for biomarker discovery, the potential association bet...

Joseph P. Dewulf, Manon Martin, Sandrine Marie, Fabie Oguz… in Scientific Reports (2022)

Article

Platypnea–orthodeoxia syndrome in a postoperative patient: a case report

We report a case of platypnea–orthodeoxia syndrome observed in a complex clinical situation associating a bilateral pleural effusion, lobar pulmonary embolism, and a partial anomalous pulmonary venous return.

João Pinto Pereira, Benoit Ghaye… in Journal of Medical Case Reports (2021)

Article

Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials

Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective...

Cathrine Axfors, Perrine Janiaud, Andreas M. Schmitt… in BMC Infectious Diseases (2021)

Article

Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial

Investigate safety and tolerability of adrecizumab, a humanized monoclonal adrenomedullin antibody, in septic shock patients with high adrenomedullin.

Pierre-François Laterre, Peter Pickkers, Gernot Marx… in Intensive Care Medicine (2021)

Article

sTREM-1 is a specific biomarker of TREM-1 pathway activation

Lucie Jolly, Kévin Carrasco, Margarita Salcedo-Magguilli… in Cellular & Molecular Immunology (2021)

Article

Correction to: A multicenter randomized trial to assess the efficacy of CONvalescent plasma therapy in patients with Invasive COVID-19 and acute respiratory failure treated with mechanical ventilation: the CONFIDENT trial protocol

Benoît Misset, Eric Hoste, Anne Françoise Donneau, David Grimaldi… in BMC Pulmonary Medicine (2021)

Article

Serum uric acid, disease severity and outcomes in COVID-19

The severity of coronavirus disease 2019 (COVID-19) is highly variable between individuals, ranging from asymptomatic infection to critical disease with acute respiratory distress syndrome requiring mechanical...

Inès Dufour, Alexis Werion, Leila Belkhir, Anastazja Wisniewska… in Critical Care (2021)

Article

The causal relationship between O2:K7:H6 extra-intestinal pathogenic Escherichia coli (ExPEC) and native valve endocarditis: a case report

Native valves infective endocarditis due to Escherichia coli is still a rare disease and a particular virulence of some E.coli isolate may be suspected.

Marie-Françoise Leonard, Hector Rodriguez-Villalobos… in BMC Infectious Diseases (2021)

Article

Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study

Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the degradation of various cardiovascular and endorphin mediators. High levels of circulating DPP3 (cDPP3) indicate a high risk of organ dysfunct...

Alice Blet, Benjamin Deniau, Karine Santos, Dirk P. T. van Lier… in Critical Care (2021)

Article

A multicenter randomized trial to assess the efficacy of CONvalescent plasma therapy in patients with Invasive COVID-19 and acute respiratory failure treated with mechanical ventilation: the CONFIDENT trial protocol

The COVID-19 pandemic reached Europe in early 2020. Convalescent plasma is used without a consistent evidence of efficacy. Our hypothesis is that passive immunization with plasma collected from patients having...

Benoît Misset, Eric Hoste, Anne-Françoise Donneau, David Grimaldi… in BMC Pulmonary Medicine (2020)

Article

A phase Ib/IIa, randomised, double-blind, multicentre trial to assess the safety and efficacy of expanded Cx611 allogeneic adipose-derived stem cells (eASCs) for the treatment of patients with community-acquired bacterial pneumonia admitted to the intensive care unit

Community-acquired bacterial pneumonia (CABP) can lead to sepsis and is associated with high mortality rates in patients presenting with shock and/or respiratory failure and who require mechanical ventilation ...

Pierre-François Laterre, Miguel Sánchez-García, Tom van der Poll… in BMC Pulmonary Medicine (2020)

Article

New Agents in Development for Sepsis: Any Reason for Hope?

Sepsis is a syndrome which is defined as a dysregulated host response to infection leading to organ failure. Since it remains one of the leading causes of mortality worldwide, numerous drug candidates have alr...

Philippe Vignon, Pierre-François Laterre, Thomas Daix, Bruno François in Drugs (2020)

Article

Surgical mask on top of high-flow nasal cannula improves oxygenation in critically ill COVID-19 patients with hypoxemic respiratory failure

Critically ill patients admitted in ICU because of COVID-19 infection display severe hypoxemic respiratory failure. The Surviving Sepsis Campaign recommends oxygenation through high-flow nasal cannula over non...

Virginie Montiel, Arnaud Robert, Annie Robert, Anas Nabaoui… in Annals of Intensive Care (2020)

Article

Prognostic performance of endothelial biomarkers to early predict clinical deterioration of patients with suspected bacterial infection and sepsis admitted to the emergency department

The objective of this study was to evaluate the ability of endothelial biomarkers to early predict clinical deterioration of patients admitted to the emergency department (ED) with a suspected sepsis. This was...

Thomas Lafon, Marie-Angélique Cazalis, Christine Vallejo… in Annals of Intensive Care (2020)