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Article
Open AccessLow quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients
In addition to an inflammatory reaction, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-infected patients present lymphopenia, which we recently reported as being related to abnormal programmed c...
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Article
Open AccessT cell apoptosis characterizes severe Covid-19 disease
Severe SARS-CoV-2 infections are characterized by lymphopenia, but the mechanisms involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized that SARS-CoV-2 infection-mediated l...
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Article
Open AccessUltrafast dynamics of heme distortion in the O2-sensor of a thermophilic anaerobe bacterium
Heme-Nitric oxide and Oxygen binding protein domains (H-NOX) are found in signaling pathways of both prokaryotes and eukaryotes and share sequence homology with soluble guanylate cyclase, the mammalian NO rece...
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Article
Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes
The oxylipin pathway generates not only prostaglandin-like jasmonates but also green leaf volatiles (GLVs), which confer characteristic aromas to fruits and vegetables. Although allene oxide synthase (AOS) and...
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Chapter and Conference Paper
Understanding the NO-Sensing Mechanism at Molecular Level
We present here how ultrafast time-resolved spectroscopy improves our understanding of a new class of proteins: Nitric Oxide sensors. Nitric oxide (NO) is a small, short-lived, and highly reactive gaseous mole...
