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Open AccessCorrection: Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells
The PDF and HTML versions of the article have been updated to include the Creative Commons Attribution 4.0 International License information.
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Article
Open AccessOsteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells
Stimulating bone formation is an important challenge for bone anabolism in osteoporotic patients or to repair bone defects. The osteogenic properties of matrix glycosaminoglycans (GAGs) have been explored; how...
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Article
Osteoblast dysfunctions in bone diseases: from cellular and molecular mechanisms to therapeutic strategies
Several metabolic, genetic and oncogenic bone diseases are characterized by defective or excessive bone formation. These abnormalities are caused by dysfunctions in the commitment, differentiation or survival ...
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Article
Cadherin-Mediated Cell–Cell Adhesion and Signaling in the Skeleton
Direct cell-to-cell interactions via cell adhesion molecules, in particular cadherins, are critical for morphogenesis, tissue architecture, and cell sorting and differentiation. Partially overlap**, yet dist...
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Article
Targeting integrins to promote bone formation and repair
Age-related bone loss can eventually result in osteoporosis. In this Review, Pierre Marie describes an emerging therapy that involves targeting certain integrin transmembrane proteins to promote the differenti...
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Article
Signaling Pathways Affecting Skeletal Health
Skeletal health is dependent on the balance between bone resorption and formation during bone remodeling. Multiple signaling pathways play essential roles in the maintenance of skeletal integrity by positively...
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Osteoblast Biology and Mechanosensing
The skeleton adapts to unloading and loading by changes in bone formation and bone mass. Mechanical forces induce several effects on bone formation through direct and indirect effects on osteoblastogenesis. Di...
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Article
Open AccessCrosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation
The potential of mesenchymal stromal cells (MSCs) to differentiate into functional bone forming cells provides an important tool for bone regeneration. The identification of factors that trigger osteoblast dif...
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Article
Topographically induced self-deformation of the nuclei of cells: dependence on cell type and proposed mechanisms
Osteosarcoma-derived cell lines (SaOs-2, MG63) have recently been shown to deform their nucleus considerably in response to surface topography. Such a deformation had not been described previously. Here we pre...
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Chapter
FGF/FGFR Signaling in Skeletal Dysplasias
Fibroblast growth factor (FGF) signaling plays an important role during endochondral and intramembranous bone development. The identification of skeletal abnormalities induced by genetic mutations in FGF recep...
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Chapter
Effects of Microgravity on Skeletal Remodeling and Bone Cells
The skeleton is a complex living tissue that serves multiple functions, such as mechanical support of the body, protection of the vital organs, and reservoir of minerals. Gravity and loading exert important ef...
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Article
Protein production by osteoblasts: modulation by breast cancer cell-derived factors
Breast cancer cells (BCC) frequently metastasize to bone where they may cause tumor-induced osteolysis (TIO). While the important eroding role of the osteoclasts in TIO is well admitted, the possibility that B...
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Article
Short-term effects of organic silicon on trabecular bone in mature ovariectomized rats
Silicon is known to ensure an essential role in the formation of cross-links between collagen and proteoglycans during bone growth. In this study, we have evaluated the short-term effects of a preventive treat...
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Culture and behavior of osteoblastic cells isolated from normal trabecular bone surfaces
We report the characterization of human osteoblastic cells that were derived from the surface of trabecular bone fragments. After removal of bone marrow cells, the bone lining osteoblastic cells lining the bon...
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Article
Alkaline phosphatase inhibition by levamisole prevents 1,25-dihydroxyvitamin D3-stimulated bone mineralization in the mouse
To determine the relationship between alkaline phosphatase (AP), 1,25(OD)2D3 and bone formationin vivo, we have examined the effects of levamisole, a stereospecific inhibitor of AP on bone formation and on 1,25(O...
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Article
The effect of differing dietary calcium and phosphorus contents on mineral metabolism and bone histomorphometry in young vitamin D-replete baboons
Young baboons were fed semisynthetic, vitamin D-containing diets differing in calcium and/or phosphorus content over a 16 month study period. Diets low in calcium alone or low in both calcium and phosphorus le...
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Article
Exacerbation of rickets and osteomalacia by maize: A study of bone histomorphometry and composition in young baboons
Three groups of young baboons were fed for 16 months on one of three diets. The first group was given a well-tried semisynthetic formula, the second group the same diet save that vitamin D had been omitted, an...
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Article
Continuous infusion of 1,25-dihydroxyvitamin D3 stimulates bone turnover in the normal young mouse
The effects of continuous administration of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on mineral and bone metabolism have been examined in the normal mouse. Four doses (0.05–0.25µg/kg/day) of 1,25(OH)2D3 were infuse...
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Article
Relation between hypomineralized periosteocytic lesions and bone mineralization in vitamin D-resistant rickets
Hypomineralized periosteocytic lesions (HPL) are peculiar bone features associated with osteomalacia in vitamin D-resistant rickets (VDRR). To determine whether HPL result from defective bone mineralization, t...
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Article
Influence of magnesium supplementation on bone turnover in the normal young mouse
The effect of magnesium (Mg) supplementation on bone metabolism has been studied in the normal young mouse. Weanling male mice were given Mg-supplemented drinking water (5 mM or 32 mM Mg) for 4 weeks. Mineral ...
