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  1. Article

    Open Access

    Cyclin-dependent kinases and rare developmental disorders

    Extensive studies in the past 30 years have established that cyclin-dependent kinases (CDKs) exert many diverse, important functions in a number of molecular and cellular processes that are at play during deve...

    Pierre Colas in Orphanet Journal of Rare Diseases (2020)

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    Chapter

    The European Marine Biological Research Infrastructure Cluster: An Alliance of European Research Infrastructures to Promote the Blue Bioeconomy

    Marine biotechnology is the key to harness the huge economic potential of the unique biodiversity of marine organisms. This potential remains largely underexploited due to three major issues: (1) lack of conne...

    Mery Piña, Pierre Colas, Ibon Cancio… in Grand Challenges in Marine Biotechnology (2018)

  3. No Access

    Protocol

    Peptide Aptamers for Small Molecule Drug Discovery

    Peptide aptamers have primarily been used as research tools to manipulate protein function and study regulatory networks. However, they also find multiple applications in therapeutic research, from target iden...

    Carine Bardou, Christophe Borie, Marc Bickle… in Nucleic Acid and Peptide Aptamers (2009)

  4. Article

    The eleven-year switch of peptide aptamers

    Peptide aptamers are combinatorial recognition proteins that were introduced more than ten years ago. They have since found many applications in fundamental and therapeutic research, including their recent use...

    Pierre Colas in Journal of Biology (2008)

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    Article

    Selection and characterization of large collections of peptide aptamers through optimized yeast two-hybrid procedures

    Peptide aptamers are combinatorial proteins that specifically bind intracellular proteins and modulate their function. They are powerful tools to study protein function within complex regulatory networks and t...

    Marc B T Bickle, Eric Dusserre, Olivier Moncorgé, Hélène Bottin… in Nature Protocols (2006)

  6. No Access

    Reference Work Entry In depth

    Peptide Aptamers

    Pierre Colas in Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine (2006)

  7. No Access

    Article

    Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2

    A NETWORK of interacting proteins controls the activity of cyclin-dependent kinase 2 (Cdk2) (refs 1, 2) and governs the entry of higher eukaryotic cells into S phase. Analysis of this and other genetic regulat...

    Pierre Colas, Barak Cohen, Timm Jessen, Irina Grishina, John McCoy, Roger Brent in Nature (1996)

  8. No Access

    Chapter

    The oocyte metaphase arrest

    Usually, oocyte meiosis reinitiation appears as a two step process during which release from the prophase block is followed by a second arrest in metaphase I or II. In this review, we will examine the mechanis...

    Pierre Colas, Pierre Guerrier in Progress in Cell Cycle Research (1995)