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  1. Article

    Open Access

    Complete remission of heavily treated ovarian clear cell carcinoma with ARID1A mutations after pembrolizumab and bevacizumab combination therapy: a case report

    Patients with ovarian clear cell carcinoma (OCCC) have a poor prognosis because they show low sensitivity to platinum-based chemotherapy. New treatments for refractory OCCC are urgently needed.

    Yu-Chien Lin, Kuo-Chang Wen, Pi-Lin Sung, Yu-Ting Chou in Journal of Ovarian Research (2020)

  2. Article

    Open Access

    Neoadjuvant metformin added to conventional chemotherapy synergizes anti-proliferative effects in ovarian cancer

    Ovarian cancer is the leading cause of cancer-related death among women. Complete cytoreductive surgery followed by platinum-taxene chemotherapy has been the gold standard for a long time. Various compounds ha...

    Kuo-Chang Wen, Pi-Lin Sung, Alexander T. H. Wu in Journal of Ovarian Research (2020)

  3. Article

    Open Access

    Crosstalk between SOX2 and cytokine signaling in endometrial carcinoma

    Endometrial carcinoma is a cancer derived from oncogenesis of the regenerating uterine cavity, in which cytokine stimulation shapes cell differentiation and tissue remodeling. Expression of the stem cell factors

    Chang-Jung Lee, Pi-Lin Sung, Ming-Han Kuo, Min-Hwa Tsai in Scientific Reports (2018)

  4. Article

    Open Access

    The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis

    Ovarian cancer (OCa) peritoneal metastasis is the leading cause of cancer–related deaths in women with limited therapeutic options available for treating it and poor prognosis, as the underlying mechanism is n...

    Kuo-Tai Hua, Ming-Yang Wang, Min-Wei Chen, Lin-Hung Wei, Chi-Kuan Chen in Molecular Cancer (2014)