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Article

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

NLRP3 is a cytosolic sensor triggered by different pathogen- and self-derived signals that plays a central role in a variety of pathological conditions, including sterile inflammation. The leucine-rich repeat ...

Iva Hafner-Bratkovič, Petra Sušjan, Duško Lainšček… in Nature Communications (2018)