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Retinal Imaging and Functional Biomarkers of Huntington’s Disease
The retina shares a common embryological origin with the brain and both organs have numerous anatomical and functional commonalities. The retina is the only portion of the central nervous system that is optica...
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Article
Open AccessThe AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research
In this study, we report the results of a comprehensive phenoty** of the retina of the AppNL-G-F mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progr...
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Article
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
In this study, the authors show that oligodendrocyte differentiation and remyelination after a CNS lesion coincides with a switch in microglial/macrophage polarization from a pro-inflammatory, M1, phenotype to...