8 Result(s)
within
Peter van Wijngaarden
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Article
Open AccessHyperspectral retinal imaging biomarkers of ocular and systemic diseases
Hyperspectral imaging is a frontier in the field of medical imaging technology. It enables the simultaneous collection of spectroscopic and spatial data. Structural and physiological information encoded in the...
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Chapter
Retinal Imaging and Functional Biomarkers of Huntington’s Disease
The retina shares a common embryological origin with the brain and both organs have numerous anatomical and functional commonalities. The retina is the only portion of the central nervous system that is optica...
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Article
Open AccessA survey of clinicians on the use of artificial intelligence in ophthalmology, dermatology, radiology and radiation oncology
Artificial intelligence technology has advanced rapidly in recent years and has the potential to improve healthcare outcomes. However, technology uptake will be largely driven by clinicians, and there is a pau...
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Article
Open AccessThe AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research
In this study, we report the results of a comprehensive phenoty** of the retina of the AppNL-G-F mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progr...
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Article
Open AccessNon-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease
Studies of rodent models of Alzheimer’s disease (AD) and of human tissues suggest that the retinal changes that occur in AD, including the accumulation of amyloid beta (Aβ), may serve as surrogate markers of b...
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Article
Open AccessThe validity of self-report of eye diseases in participants with vision loss in the National Eye Health Survey
We assessed the validity and reliability of self-report of eye disease in participants with unilateral vision loss (presenting visual acuity worse than 6/12 in the worse eye and equal to or better than 6/12 in...
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Article
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
In this study, the authors show that oligodendrocyte differentiation and remyelination after a CNS lesion coincides with a switch in microglial/macrophage polarization from a pro-inflammatory, M1, phenotype to...
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Article
Hereditary influences in oxygen-induced retinopathy in the rat
Rodent models of oxygen-induced retinopathy (OIR) provide important insights into the pathogenesis of human retinopathy of prematurity. Herein, we present an overview of our work with rat OIR to date. We have ...
