-
Article
Open AccessStepwise differentiation of follicular helper T cells reveals distinct developmental and functional states
Follicular helper T (Tfh) cells are essential for the formation of high affinity antibodies after vaccination or infection. Although the signals responsible for initiating Tfh differentiation from naïve T cell...
-
Article
Check(point) yourself before you wreck yourself in tumors
Expression of the inhibitory receptor PD-1 on regulatory T cells in the tumor microenvironment provides intrinsic stabilization, proliferation and metabolic rewiring signals to restrain tumor immunity.
-
Protocol
Tfh-Mediated and Tfr-Suppressed Antigen-Driven IgG and IgE Assays
T Follicular helper (Tfh) cells stimulate, whereas T follicular regulatory (Tfr) cells inhibit, effector B cell responses. Although new tools have been developed to assess the functional roles of Tfh and Tfr c...
-
Article
Open AccessDonor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo
Solid organ transplantation is a lifesaving therapy for patients with end-organ disease. Current immunosuppression protocols are not designed to target antigen-specific alloimmunity and are uncapable of preven...
-
Article
Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses
Follicular regulatory T (TFR) cells have specialized roles in modulating follicular helper T (TFH) cell activation of B cells. However, the precise role of TFR cells in controlling antibody responses to foreign a...
-
Article
Suppression by TFR cells leads to durable and selective inhibition of B cell effector function
Follicular regulatory T cells (TFR cells) inhibit follicular helper T cell (TFH cell)-mediated antibody production. Sharpe and colleagues show that TFR cells induce a distinct suppressive state in TFH cells and B...
-
Article
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability
Regulatory T cells normally maintain high expression of the phosphatase PTEN. Turka and colleagues use conditional deletion of PTEN in regulatory T cells to show that it is critical for their function and stab...
-
Protocol
In Vitro Assay to Sensitively Measure Tfr Suppressive Capacity and Tfh Stimulation of B Cell Responses
T follicular helper (Tfh) cells stimulate, whereas T follicular regulatory (Tfr) cells inhibit, B cell responses. Despite the potent immunoregulatory roles for Tfr cells in controlling the magnitude of antibody p...
-
Article
The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood
Follicular regulatory T cells control humoral immune responses, but how these cells are in turn controlled has been unclear. Sharpe and colleagues demonstrate that signaling via PD-1 regulates number and funct...