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Article
Open AccessPrediction of 30-day, 90-day, and 1-year mortality after colorectal cancer surgery using a data-driven approach
To develop prediction models for short-term mortality risk assessment following colorectal cancer surgery.
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Article
Open AccessAttention-based neural networks for clinical prediction modelling on electronic health records
Deep learning models have had a lot of success in various fields. However, on structured data they have struggled. Here we apply four state-of-the-art supervised deep learning models using the attention mechan...
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Article
Open AccessSupporting Pharmacovigilance Signal Validation and Prioritization with Analyses of Routinely Collected Health Data: Lessons Learned from an EHDEN Network Study
Individual case reports are the main asset in pharmacovigilance signal management. Signal validation is the first stage after signal detection and aims to determine if there is sufficient evidence to justify f...
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Article
Open AccessDrug Utilisation Patterns of Alternatives to Ranitidine-Containing Medicines in Patients Treated with Ranitidine: A Network Analysis of Data from Six European National Databases
Ranitidine, a histamine H2-receptor antagonist (H2RA), is indicated in the management of gastric acid-related disorders. In 2020, the European Medicines Agency (EMA) recommended suspension of all ranitidine-conta...
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Article
Impact of European Union Label Changes for Fluoroquinolone-Containing Medicinal Products for Systemic and Inhalation Use: Post-Referral Prescribing Trends
Concerns of the persistence and severity of the adverse effects of fluoroquinolones, mainly involving the nervous system, muscles and joints, resulted in the 2018 referral procedure led by the European Medicin...
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Article
Open AccessThrombosis and thrombocytopenia after vaccination against and infection with SARS-CoV-2 in Catalonia, Spain
Population-based studies can provide important evidence on the safety of COVID-19 vaccines. Here we compare rates of thrombosis and thrombocytopenia following vaccination against SARS-CoV-2 with the background...
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Article
Open AccessCommon Problems, Common Data Model Solutions: Evidence Generation for Health Technology Assessment
There is growing interest in using observational data to assess the safety, effectiveness, and cost effectiveness of medical technologies, but operational, technical, and methodological challenges limit its mo...
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Article
Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe
Real-world studies to describe the use of first, second and third line therapies for the management and symptomatic treatment of dementia are lacking. This retrospective cohort study describes the first-, seco...
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Article
Open AccessAn empirical analysis of dealing with patients who are lost to follow-up when develo** prognostic models using a cohort design
Researchers develo** prediction models are faced with numerous design choices that may impact model performance. One key decision is how to include patients who are lost to follow-up. In this paper we perfor...
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Article
Open AccessDeep phenoty** of 34,128 adult patients hospitalised with COVID-19 in an international network study
Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. ...
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Article
Open AccessFeasibility and evaluation of a large-scale external validation approach for patient-level prediction in an international data network: validation of models predicting stroke in female patients newly diagnosed with atrial fibrillation
To demonstrate how the Observational Healthcare Data Science and Informatics (OHDSI) collaborative network and standardization can be utilized to scale-up external validation of patient-level prediction models...
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Article
Open AccessMethotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study
Inflammatory processes have been shown to play a role in dementia. To understand this role, we selected two anti-inflammatory drugs (methotrexate and sulfasalazine) to study their association with dementia risk.
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Article
Open AccessTASKA: A modular task management system to support health research studies
Many healthcare databases have been routinely collected over the past decades, to support clinical practice and administrative services. However, their secondary use for research is often hindered by restricte...
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Article
Open AccessRisks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohorts
Non-alcoholic fatty liver disease (NAFLD) is a common condition that progresses in some patients to steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). Here we used healthcare records of 18 m...
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Article
Open AccessReal-world data reveal a diagnostic gap in non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide. It affects an estimated 20% of the general population, based on cohort studies of varying size and heterogeneous s...
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Article
Open AccessPrediction of RNA-protein sequence and structure binding preferences using deep convolutional and recurrent neural networks
RNA regulation is significantly dependent on its binding protein partner, known as the RNA-binding proteins (RBPs). Unfortunately, the binding preferences for most RBPs are still not well characterized. Interd...
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Article
Erratum to: Antibiotic use varies substantially among adults: a cross-national study from five European Countries in the ARITMO project
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Article
Antibiotic use varies substantially among adults: a cross-national study from five European Countries in the ARITMO project
To examine patterns of outpatient and community antibiotic use among adults in five European countries.
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Article
Effectiveness of risk minimization measures for cabergoline-induced cardiac valve fibrosis in clinical practice in Italy
On June 2008, the European Medicines Agency (EMA) introduced changes to the Summary of Product Characteristics (SPC) for cabergoline and pergolide, to reduce the risk of cardiac valvulopathy in users of these ...
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Chapter and Conference Paper
Alignment of 4D Coronary CTA with Monoplane X-ray Angiography
We propose a 3D+t/2D+t registration strategy to relate preoperative CTA to intraoperative X-ray angiography for improved image guidance during coronary interventions. We first derive 4D coronary models from CT...
