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Open AccessRadical thioesterification via nickel-catalysed sensitized electron transfer
Multi-catalytic reaction modes have attracted widespread attention in synthetic chemistry. The merger of nickel catalysis with photoredox catalysis has offered a powerful platform for synthesis of molecules wi...
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Photochemical single-step synthesis of β-amino acid derivatives from alkenes and (hetero)arenes
β-Amino acids are frequently found as important components in numerous biologically active molecules, drugs and natural products. In particular, they are broadly utilized in the construction of bioactive pepti...
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Catalytic multicomponent reaction involving a ketyl-type radical
The development of new strategies and concepts towards the synthetic utilization of carbonyl compounds is of pivotal relevance. Nevertheless, the generation of ketyl radicals requires relatively harsh conditio...
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Open AccessFacile access to fused 2D/3D rings via intermolecular cascade dearomative [2 + 2] cycloaddition/rearrangement reactions of quinolines with alkenes
Hybrid fused two-dimensional/three-dimensional (2D/3D) rings are important pharmacophores in drugs owing to their unique structural and physicochemical properties. Preparation of these strained ring systems of...
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Allylic C(sp3)–H arylation of olefins via ternary catalysis
Transforming C(sp3)–H bonds efficiently and selectively into C(sp3)–C(sp3) or C(sp3)–X bonds is a highly relevant task. The direct arylation of allylic C(sp3)–H bonds provides an elegant method for the formation ...
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Recent advances in the chemistry and applications of N-heterocyclic carbenes
N-Heterocyclic carbenes, despite being isolated and characterized three decades ago, still capture scientists’ interest as versatile, modular and strongly coordinating moieties. In the last decade, driven by t...
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N-Heterocyclic carbenes as tunable ligands for catalytic metal surfaces
Heterogeneous catalysts represent the backbone of many industrial processes and thus have a considerable societal impact. The active sites of these heterogeneous catalysts are often metal surfaces, which consi...
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Bifunctional reagents in organic synthesis
Developments in synthetic chemistry are increasingly driven by improvements in the selectivity and sustainability of transformations. Bifunctional reagents, either as dual coupling partners or as a coupling pa...