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Article
Could retaining the dental recall interval save NHS dentistry?
The World Health Assembly in May 2021 was a watershed moment in oral health, with the landmark resolution that designated oral diseases as non-communicable diseases (NCDs). This was strongly supported by a hos...
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Article
Open AccessUtilising massive open online courses to enhance global learning dissemination in cleft lip and palate: a case report of penta helix collaboration
Educating and raising awareness in cleft lip and palate future generations is one vital effort to ensure the improvement of cleft care and research in the future. This study reported the overview in organising...
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Article
Open AccessPerceptions and beliefs of community gatekeepers about genomic risk information in African cleft research
A fundamental ethical issue in African genomics research is how socio-cultural factors impact perspectives, acceptance, and utility of genomic information, especially in stigmatizing conditions like orofacial ...
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Article
Global perspectives in orofacial cleft management and research
Orofacial clefts (OFCs) refer to clefts of the lip and palate, a heterogeneous group of relatively common congenital conditions that can cause mortality and significant disability if untreated, and residual mo...
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Article
Dental education at Dundee Dental Hospital and School - a notable past and inspiring future
Dundee Dental Hospital and School has been present on Park Place, Dundee for over 100 years. During this time, it has been at the forefront of dental care and education, first as part of the University of St A...
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Article
Open AccessWhole-genome sequencing reveals de-novo mutations associated with nonsyndromic cleft lip/palate
The majority (85%) of nonsyndromic cleft lip with or without cleft palate (nsCL/P) cases occur sporadically, suggesting a role for de novo mutations (DNMs) in the etiology of nsCL/P. To identify high impact pr...
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Article
Open AccessA 3D cephalometric protocol for the accurate quantification of the craniofacial symmetry and facial growth
Cephalometric analysis is used to evaluate facial growth, to study the anatomical relationships within the face. Cephalometric assessment is based on 2D radiographic images, either the sagittal or coronal plan...
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Article
Open AccessNose profile morphology and accuracy study of nose profile estimation method in Scottish subadult and Indonesian adult populations
This study investigated nose profile morphology and its relationship to the skull in Scottish subadult and Indonesian adult populations, with the aim of improving the accuracy of forensic craniofacial reconstr...
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Article
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci
Elisabeth Mangold and colleagues report a genome-wide meta-analyses of non-syndromic cleft lip with or without cleft palate (NSCL/P). They report six new genetic loci associated with risk for NSCL/P.
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Article
Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
Elisabeth Mangold and colleagues report a genome-wide association study for non-syndromic cleft lip with or without cleft palate.
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Article
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24
Elisabeth Mangold and colleagues carried out a genome-wide association study for nonsyndromic cleft lip with or without cleft palate, and report a locus on 8q24.21 that is strongly associated with this phenotype.
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Article
Disruption of an AP-2α binding site in an IRF6 enhancer is associated with cleft lip
Nonsyndromic cleft lip with or without cleft palate has been associated with SNPs in the IRF6 gene. Now Jeff Murray and colleagues report the identification of a common variant in a previously unknown IRF6 enhanc...
