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Article
Open AccessResearch on the bearing creep characteristics and constitutive model of gangue filling body
The creep characteristics and potential deformation patterns of gangue backfill material are crucial in backfill mining operations. This study utilizes crushed gangue from the Gangue Yard in Fuxin City as the ...
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Article
Open AccessThe deubiquitinating enzyme USP4 regulates BRCA1 stability and function
BRCA1 plays a suppressive role in breast tumorigenesis. Ubiquitin-dependent degradation is a common mechanism that regulates BRCA1 protein stability, and several ubiquitin ligases involved have been identified...
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Article
The Effect of Extrusion Ratio on the Discharge and Corrosion Behavior of Mg-3Al-2.8Y-0.7Mn Alloy
In this study, the impact of extrusion ratio (ER: 10, 16, and 25) on the electrochemical behaviors and discharge performances of Mg-3Al-2.8Y-0.7Mn (wt.%) alloys was investigated. The results indicate that an i...
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Article
Anti-fouling and Hydrophobic Polyurethane Fibrous Membrane for Air Purification Under High Humidity Conditions
With the rapid development of urbanization and industrialization, air pollution is increasingly harmful to life on earth. At present, purifying polluted air through functional filter materials is an effective ...
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Article
Open AccessDownregulation of UBB potentiates SP1/VEGFA-dependent angiogenesis in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) presents a unique profile characterized by high levels of angiogenesis and robust vascularization. Understanding the underlying mechanisms driving this heterogeneity is ...
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Article
Open AccessMutation breeding of high-stress resistant strains for succinic acid production from corn straw
The production of succinic acid from corn stover is a promising and sustainable route; however, during the pretreatment stage, byproducts such as organic acids, furan-based compounds, and phenolic compounds ge...
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Article
Development of a hypoxia-activated red-emission fluorescent probe for in vivo tumor microenvironment imaging and anti-tumor therapy
Hypoxia, a significant feature of the tumor microenvironment, is closely associated with tumor growth, metastasis, and drug resistance. In the field of tumor microenvironment analysis, accurately imaging and q...
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Article
Lycorine hydrochloride interferes with energy metabolism to inhibit chemoresistant glioblastoma multiforme cell growth through suppressing PDK3
Glioblastoma multiforme (GBM) is the highest grade of glioma. Tumours, including GBM, possess reprogrammed metabolism, such as altered aerobic glycolysis and aberrant energy production. Lycorine hydrochloride ...
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Article
Open AccessAptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential anti pan-coronavirus activity
Emerging and recurrent infectious diseases caused by human coronaviruses (HCoVs) continue to pose a significant threat to global public health security. In light of this ongoing threat, the development of a br...
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Article
Open AccessKisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src
Osteoclasts are over-activated as we age, which results in bone loss. Src deficiency in mice leads to severe osteopetrosis due to a functional defect in osteoclasts, indicating that Src function is essential in o...
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Article
Open AccessExosomal circZNF800 Derived from Glioma Stem-like Cells Regulates Glioblastoma Tumorigenicity via the PIEZO1/Akt Axis
Exosomes play a crucial role in regulating crosstalk between tumor and tumor stem-like cells through their cargo molecules. Circular RNAs (circRNAs) have recently been demonstrated to be critical factors in tu...
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Article
Experimental Study on the Fracture Process Zones and Fracture Characteristics of Coal and Rocks in Coal Beds
In this work, the physical, mechanical, and fracturing properties of three different types of rock (shale, sandstone, and coal) are studied through three-point bending tests. The fracturing characteristics are...
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Article
Open AccessEndometrioid carcinomas with sex cord-like formations and hyalinization: spontaneous pregnancy after conservative treatment
Endometrioid carcinoma with sex cord-like formations and hyalinization of the uterine corpus, or corded and hyalinized endometrioid adenocarcinoma (CHEC), is a rare morphological variant of endometrioid carcin...
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Chapter and Conference Paper
Generating Architectural Floor Plans Through Conditional Large Diffusion Model
This paper introduces a novel method for generating architectural floor plans using Conditional Large Diffusion Models to migrate the limitations of existing generative methods, such as restrictions on rectili...
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Chapter and Conference Paper
Beyond Volume Pattern: Storage-Efficient Boolean Searchable Symmetric Encryption with Suppressed Leakage
Boolean Searchable Symmetric Encryption (BSSE) enables users to perform retrieval operations on the encrypted data while supporting complex query capabilities. This paper focuses on addressing the storage over...
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Article
Open AccessThe pregnancy and oncology outcome of fertility-sparing management for synchronous primary neoplasm of endometrium and ovary
To investigate the efficacy of fertility-preserving treatment for young women with synchronous primary neoplasm of endometrium and ovary.
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Article
Investigation on the preparation and finishing performance of a novel nanoparticle-enhanced bonded magnetic abrasive
In response to the shortcomings of existing bonded magnetic abrasives, such as poor finishing performance, short service life, and insufficient mechanical properties of the binder, a preparation method for the...
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Article
Open AccessA Cellular Senescence-Related Signature Predicts Cervical Cancer Patient Outcome and Immunotherapy Sensitivity
Cervical cancer (CC) is one of the most prevalent gynecological malignancies. The rate of mortality and morbidity among patients with CC is high. Cellular senescence is involved in tumorigenesis as well as in ...
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Article
Cost-effectiveness of open pancreaticoduodenectomy with or without Heidelberg TRIANGLE operation for pancreatic cancer in China
Pancreatic cancer is a digestive malignancy with dismal prognosis. The advent of Heidelberg TRIANGLE dissection technique brings a turning point to improve the chance of survival. Our study aimed to evaluated ...
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Article
Open AccessTranscriptomic landscape based on annotated clinical features reveals PLPP2 involvement in lipid raft-mediated proliferation signature of early-stage lung adenocarcinoma
Image-based screening improves the detection of early-stage lung adenocarcinoma (LUAD)but also highlights the issue of high false-positive diagnoses, which puts patients at a risk of unnecessary over-treatment...
