9 Result(s)

Article

Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors

Aminoacyl-tRNA synthetases (aaRSs) play a central role in the translation of genetic code, serving as attractive drug targets. Within this family, the lysyl-tRNA synthetase (LysRS) constitutes a promising anti...

**tong Zhou, Mingyu **a, Zhenghui Huang, Hang Qiao, Guang Yang… in Communications Biology (2024)

Article

Publisher Correction: GOSS: towards generalized open-set semantic segmentation

Jie Hong, Weihao Li, Junlin Han, Jiyang Zheng, Pengfei Fang… in The Visual Computer (2024)

Article

GOSS: towards generalized open-set semantic segmentation

In this paper, we extend Open-set Semantic Segmentation (OSS) into a new image segmentation task called Generalized Open-set Semantic Segmentation (GOSS). Previously, with well-known OSS, the intelligent agent...

Jie Hong, Weihao Li, Junlin Han, Jiyang Zheng, Pengfei Fang… in The Visual Computer (2024)

Article

Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion

Aminoacyl-tRNA synthetases (AARSs), a family of essential protein synthesis enzymes, are attractive targets for drug development. Although several different types of AARS inhibitors have been identified, AARS ...

Hang Qiao, Mingyu **a, Yiyuan Cheng, **tong Zhou, Li Zheng… in Communications Biology (2023)

Article

Second messenger Ap₄A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells

Signal transduction systems enable organisms to monitor their external environments and accordingly adjust the cellular processes. In mast cells, the second messenger Ap₄A binds to the histidine triad nucleotide-...

**g Yu, Zaizhou Liu, Yuanyuan Liang, Feng Luo, Jie Zhang… in Nature Communications (2019)

Article

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

Metastasis is the main cause of death in cancer patients. TGF-β is pro-metastatic for malignant cancer cells. Here we report a loss-of-function screen in mice with metastasis as readout and identify OTUD1 as a...

Zhengkui Zhang, Yao Fan, Feng **e, Hang Zhou, Ke **, Li Shao… in Nature Communications (2017)

Article

Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor

Aminoacyl-tRNA synthetases (AARSs) catalyze an early step in protein synthesis, but also regulate diverse physiological processes in animal cells. These include angiogenesis and human threonyl-tRNA synthetase ...

Adam C. Mirando, Pengfei Fang, Tamara F. Williams, Linda C. Baldor… in Scientific Reports (2015)

Article

Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase

The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrR...

Pengfei Fang, Xue Yu, Seung Jae Jeong, Adam Mirando, Kaige Chen… in Nature Communications (2015)

Article

Quick and Facile Preparation of Visible light-Driven TiO₂ Photocatalyst with High Absorption and Photocatalytic Activity

Self-do** TiO₂ has recently attracted considerable attention for its high photocatalytic activity under visible-light irradiation. However, the literature reported synthetic methods until now were very time-con...

Yucheng Yang, Ting Zhang, Ling Le, Xuefeng Ruan, Pengfei Fang… in Scientific Reports (2014)