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  1. Article

    Open Access

    Discovery of novel JAK1 inhibitors through combining machine learning, structure-based pharmacophore modeling and bio-evaluation

    Janus kinase 1 (JAK1) plays a critical role in most cytokine-mediated inflammatory, autoimmune responses and various cancers via the JAK/STAT signaling pathway. Inhibition of JAK1 is therefore an attractive th...

    Zixiao Wang, Lili Sun, Yu Xu, Peida Liang, Kaiyan Xu… in Journal of Translational Medicine (2023)

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  2. No Access

    Article

    MrgX2-SNAP-tag/cell membrane chromatography model coupled with liquid chromatography-mass spectrometry for anti-pseudo-allergic compound screening in Arnebiae Radix

    Pseudo-allergic reactions (PARs) are IgE-independent hypersensitivity reactions. Mas-related G protein-coupled receptor-X2 (MrgX2) was proved the key receptor of PAR. The anti-pseudo-allergic compound discover...

    Qianqian Jia, Jia Fu, Chunlei Gao, Hong Wang… in Analytical and Bioanalytical Chemistry (2022)

  3. Article

    Screening and evaluation of anti-SARS-CoV-2 components from Ephedra sinica by ACE2/CMC-HPLC-IT-TOF-MS approach

    Traditional Chinese medicines played an important role in the treatment of COVID-19 in 2020. Ephedra sinica, one of the major constituent herbs of multi-component herbal formula, has been widely used to treat COV...

    Yanni Lv, Saisai Wang, Peida Liang, Yamin Wang… in Analytical and Bioanalytical Chemistry (2021)

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  4. No Access

    Article

    Construction of graphene quantum dots-decorated EGFR cell membrane chromatography for screening active components from Peucedanum praeruptorum Dunn

    A novel stability-enhanced graphene quantum dot (GQD)-decorated epidermal growth factor receptor (EGFR) cell membrane chromatography was constructed to study the potential application of GQDs in bioaffinity ch...

    Liyang Zhang, **nyao Yi, Saisai Wang, Peida Liang… in Analytical and Bioanalytical Chemistry (2021)