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  1. No Access

    Article

    Iridium and B(C6F5)3 co-catalyzed chemoselective deoxygenative reduction of tertiary amides: application to the efficient synthesis and late-stage modification of pharmaceuticals

    The Vaska’s complex—tris(pentafluorophenyl)borane combination was found to be a highly efficient cooperative catalysis system for the hydrosilylative reduction of tertiary amides to yield amines under mild con...

    Feng Han, Guang-Sheng Lu, Dong-** Wu, Pei-Qiang Huang in Science China Chemistry (2023)

  2. No Access

    Article

    Catalytic diastereoselective and enantioconvergent C(sp3)—C(sp3) cross-coupling of racemic partners

    Ai-E Wang, Pei-Qiang Huang in Science China Chemistry (2020)

  3. No Access

    Article

    Ni-catalyzed direct alcoholysis of N-acylpyrrole-type tertiary amides under mild conditions

    N-Acylpyrrole-type amides are a class of versatile building blocks in asymmetric synthesis. We report that by employing Ni(COD)2/2,2′-bipyridine (5 mol%) catalytic system, the direct, catalytic alcoholysis of N-a...

    Hang Chen, Dong-Huang Chen, Pei-Qiang Huang in Science China Chemistry (2020)

  4. No Access

    Article

    Amides as surrogates of aldehydes for C-C bond formation: amide-based direct Knoevenagel-type condensation reaction and related reactions

    Aldehydes are perhaps the most versatile compounds that enable many C-C bond forming reactions, which are not amenable for other subclasses of carbonyl compounds. We report the first use of amides as surrogate...

    Wei Ou, Pei-Qiang Huang in Science China Chemistry (2020)

  5. No Access

    Article

    Metal-free synthesis of quinolines by direct condensation of amides with alkynes: revelation of N-aryl nitrilium intermediates by 2D NMR techniques

    Employing triflic anhydride/2-fluoropyridine as an activation system, the coupling reactions of secondary N-aryl amides with terminal alkynes yielded substituted quinolines in moderate to excellent yields. The re...

    Jian-Liang Ye, Ya-Nan Zhu, Hui Geng, Pei-Qiang Huang in Science China Chemistry (2018)

  6. No Access

    Article

    Tf2O-TMDS combination for the direct reductive transformation of secondary amides to aldimines, aldehydes, and/or amines

    The direct partial reduction of highly stable secondary amides to more reactive aldimines and aldehydes is a challenging yet highly demanding transformation. In this context, only three methods have been repor...

    Qi-Wei Lang, **u-Ning Hu, Pei-Qiang Huang in Science China Chemistry (2016)

  7. No Access

    Article

    Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation

    The orphan nuclear receptor Nur77 blocks inflammation through inhibition of p65 DNA binding and is suppressed by p38α-mediated phosphorylation. A small-molecule compound, PDNPA, disrupts p38α-Nur77 interaction...

    Li Li, Yuan Liu, Hang-zi Chen, Feng-wei Li, Jian-feng Wu… in Nature Chemical Biology (2015)

  8. No Access

    Article

    The first enantioselective total synthesis of (+)-preussin B and an improved synthesis of (+)-preussin by step-economical methods

    The first enantioselective total synthesis of (+)-preussin B and an improved synthesis of the antifungal alkaloid (+)-preussin are described. Our approach relied on the four step-economical synthetic methods d...

    Pei-Qiang Huang, Hui Geng, Yong-Song Tian, Qiu-Ran Peng… in Science China Chemistry (2015)

  9. No Access

    Article

    Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

    TR3 is an orphan nuclear receptor with roles in apoptosis. A TR3-binding compound induces mitochondrial translocation of TR3 and autophagy via the Nix–Toms–ANT1/VDAC1 pathway, providing a mechanism for cell de...

    Wei-jia Wang, Yuan Wang, Hang-zi Chen, Yong-zhen **ng… in Nature Chemical Biology (2014)

  10. No Access

    Article

    The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK

    A small molecule that disrupts interaction between Nur77 and LKB1 leads to LKB1 exit from the nucleus to activate cytoplasmic AMPK and, ultimately, reduces blood glucose and insulin in diabetic mice. ...

    Yan-yan Zhan, Yan Chen, Qian Zhang, Jia-jia Zhuang, Min Tian… in Nature Chemical Biology (2012)