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Open AccessSusceptibility to eye diseases in relation to age and kidney failure among Taiwanese adults
The kidney and eyes share common pathways and are thought to be closely connected. Chronic kidney disease and major eye diseases, such as cataract and glaucoma, are strongly associated with age. However, furth...
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Article
Open AccessIn silico prediction of immune-esca** hot spots for future COVID-19 vaccine design
The COVID-19 pandemic has had a widespread impact on a global scale, and the evolution of considerable dominants has already taken place. Some variants contained certain key mutations located on the receptor b...
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Open AccessPublisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries
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Open AccessStroke genetics informs drug discovery and risk prediction across ancestries
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-an...
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Open AccessRisk of HBV infection among male and female first-time blood donors born before and after the July 1986 HBV vaccination program in Taiwan
In July 1984, Taiwan officially began a nationwide hepatitis B virus (HBV) vaccination program where only infants born to HBsAg-positive mothers were vaccinated free of charge until June 1986. However, from Ju...
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Open AccessAssociation between hypertension and coffee drinking based on CYP1A2 rs762551 single nucleotide polymorphism in Taiwanese
Hypertension increases the likelihood of cardiovascular diseases (CVDs). Cytochrome P450 1A2 (CYP1A2) single nucleotide polymorphism (SNP) is related to caffeine metabolism and the risk of CVD among coffee dri...
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Open AccessPM2.5 exposure and DLEC1 promoter methylation in Taiwan Biobank participants
Particulate matter (PM) < 2.5 μm (PM2.5) or fine PM is a serious public health concern. It affects DNA methylation and heightens carcinogenesis. Deleted in lung and esophageal cancer 1 (DLEC1) is a tumor suppress...
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Open AccessAHRR cg05575921 methylation in relation to smoking and PM2.5 exposure among Taiwanese men and women
Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. AHRR cg05575921 and coa...
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Open AccessMethylation at cg05575921 of a smoking-related gene (AHRR) in non-smoking Taiwanese adults residing in areas with different PM2.5 concentrations
DNA methylation is associated with cancer, metabolic, neurological, and autoimmune disorders. Hypomethylation of aryl hydrocarbon receptor repressor (AHRR) especially at cg05575921 is associated with smoking a...
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Open AccessSOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areas
Both SOX2 promoter methylation and air pollution have been associated with lung cancer risk. However, little has been done to assess SOX2 promoter methylation in individuals living in air pollution areas. The ...
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Application of GnRH antagonist in combination with clomiphene citrate and hMG for patients with exaggerated ovarian response in previous IVF/ICSI cycles
To investigate if the combination of clomiphene citrate, hMG, and cetrorelix (CC/hMG/cetrorelix protocol) can be applied to patients who had excessive response to GnRHa long protocol.
