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Article
MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner
H3K4me1 methyltransferases MLL3 (KMT2C) and MLL4 (KMT2D) are critical for enhancer activation, cell differentiation and development. However, roles of MLL3/4 enzymatic activities and MLL3/4-mediated enhancer H...
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Article
Enhancer–promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness
How enhancers activate their distal target promoters remains incompletely understood. Here we dissect how CTCF-mediated loops facilitate and restrict such regulatory interactions. Using an allelic series of mo...
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Article
Open AccessExtensive co-binding and rapid redistribution of NANOG and GATA6 during emergence of divergent lineages
Fate-determining transcription factors (TFs) can promote lineage-restricted transcriptional programs from common progenitor states. The inner cell mass (ICM) of mouse blastocysts co-expresses the TFs NANOG and...
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Article
Open AccessAn epigenome atlas of neural progenitors within the embryonic mouse forebrain
A comprehensive characterization of epigenomic organization in the embryonic mouse forebrain will enhance our understanding of neurodevelopment and provide insight into mechanisms of neurological disease. Here...
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Article
Open AccessCavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function
TCR stimulation triggers Ca2+ signals that are critical for T cell function and immunity. Several pore-forming α and auxiliary β subunits of voltage-gated Ca2+ channels (VGCC) were reported in T cells, but their ...
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Article
Open AccessAnalysis of 3D genomic interactions identifies candidate host genes that transposable elements potentially regulate
The organization of chromatin in the nucleus plays an essential role in gene regulation. About half of the mammalian genome comprises transposable elements. Given their repetitive nature, reads associated with...
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Article
Open AccessCRISPR-dCas9 and sgRNA scaffolds enable dual-colour live imaging of satellite sequences and repeat-enriched individual loci
Imaging systems that allow visualization of specific loci and nuclear structures are highly relevant for investigating how organizational changes within the nucleus play a role in regulating gene expression an...
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Article
Open AccessErratum to: Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers
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Article
Open AccessLack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers
Over recent years, enzymes of the aldo-keto reductase (AKR) 1C subfamily have been implicated in the progression of prostate, breast, endometrial and leukemic cancers. This is due to the ability of AKR1C enzym...
