6 Result(s)
within
Pavan P. Adiseshaiah
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Protocol
Assessing NLRP3 Inflammasome Activation by Nanoparticles
NLRP3 inflammasome activation is one of the initial steps in an inflammatory cascade against pathogen/danger-associated molecular patterns (PAMPs/DAMPs), such as those arising from environmental toxins or nano...
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Protocol
Designing an In Vivo Efficacy Study of Nanomedicines for Preclinical Tumor Growth Inhibition
Novel nanoformulated chemotherapeutics and diagnostics require demonstration of efficacy and safety in appropriate animal models prior to conducting early-phase clinical trials. In vivo efficacy experiments ar...
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Protocol
Autophagy Monitoring Assay II: Imaging Autophagy Induction in LLC-PK1 Cells Using GFP-LC3 Protein Fusion Construct
Autophagy is a catabolic process involved in the degradation and recycling of long-lived proteins and damaged organelles for maintenance of cellular homeostasis, and it has also been proposed as a type II cell...
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Article
Nanotechnology as a Delivery Tool for Precision Cancer Therapies
Genomic analyses from patients with cancer have improved the understanding of the genetic elements that drive the disease, provided new targets for treating this relentless disease, and offered criteria for st...
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Article
Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancer
A nearly impenetrable stroma and hypovascularity limit drug delivery to pancreatic ductal adenocarcinoma (PDAC) cells and thus the effectiveness of treatments,...
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Article
Open AccessAutophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity
The study of the potential risks associated with the manufacture, use, and disposal of nanoscale materials, and their mechanisms of toxicity, is important for the continued advancement of nanotechnology. Curre...
