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Article
Collective Health in Brazil and Implementation Science: Challenges and Potentialities
Implementation science encounters numerous obstacles in the Latin American region, primarily due to its unique social, political, and institutional characteristics. These obstacles include weak institutions, u...
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Article
Map** genomic loci implicates genes and synaptic biology in schizophrenia
Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 con...
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Article
Open AccessKLOTHO polymorphisms and age-related outcomes in community-dwelling older subjects: The São Paulo Ageing & Health (SPAH) Study
Defective KLOTHO gene expression in mice led to a syndrome resembling human ageing. This study evaluated three KLOTHO polymorphisms, namely G395A, C1818T, and C370S, in an elderly population (mean age of 73 years...
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Article
Open AccessAcinetobacter spp. are associated with a higher mortality in intensive care patients with bacteremia: a survival analysis
It has been challenging to determine the true clinical impact of Acinetobacter spp., due to the predilection of this pathogen to colonize and infect critically ill patients, who often have a poor prognosis. The a...
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Article
Building Research Capacity Across and Within Low- and Middle-Income Countries: The Collaborative Hubs for International Research on Mental Health
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Article
Prevalence and risk factors for cannabis use in low-income pregnant women in São Paulo, Brazil
Cannabis is the most commonly used illicit drug during the perinatal period and has potential risks to the fetus. The purpose of this study is to estimate the 1-year prevalence of cannabis use and identify ass...
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Article
Population impact of depression on functional disability in elderly: results from “São Paulo Ageing & Health Study” (SPAH)
With the fast population aging, functional disability among the elderly is becoming a major public health issue. Depression is highly prevalent in this phase of life and may be associated with a significant pr...
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Article
Suicidal ideation during pregnancy: prevalence and associated factors among low-income women in São Paulo, Brazil
The aim of this study was to estimate the prevalence and correlates of suicidal ideation among low-income pregnant women living in Brazil. We performed a cross-sectional analysis of 831 women surveyed during 2...
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Article
Open AccessLoss of interest, depressed mood and impact on the quality of life: Cross-sectional survey
Depressive symptoms and chronic disease have adverse effects on patients' health-related quality of life (H-RQOL). However, little is known about this effect on H-RQOL when only the two core depressive symptom...
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Article
Open AccessSubclinical hyperthyroidism and dementia: the Sao Paulo Ageing & Health Study (SPAH)
Several epidemiologic studies have shown a possible association between thyroid function and cognitive decline. Our aim was to evaluate the association of subclinical hyperthyroidism and dementia in a populati...
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Incidence and Outcome of Schizophrenia Across the Globe
Ten years ago, during the “IV Search for the Causes of Schizophrenia” meeting, one of the main issues regarding the epidemiology of schizophrenia was the meaning and implications of universality and uniformity...
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Article
Validity of the self reporting questionnaire-20 in epidemiological studies with older adults
This study examined the validity of the self-reporting questionnaire (SRQ-20) in a population-based survey with older adults in Sao Paulo, Brazil.
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Article
Caregiver burden in an elderly population with depression in São Paulo, Brazil
Background: Mental disorders are among the most prevalent chronic conditions in old age, depression being the most widespread. The aim of this study was to examine the burden and distress reporte...
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Article
Predictors of clinical and social outcomes after hospitalization in schizophrenia
A prospective cohort study of schizophrenia was carried out in São Paulo, Brazil, in order to investigate clinical and social outcomes in schizophrenia and related psychoses after hospitalization. A sample of ...