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  1. No Access

    Article

    The homeobox transcription factor DUXBL controls exit from totipotency

    In mice, exit from the totipotent two-cell (2C) stage embryo requires silencing of the 2C-associated transcriptional program. However, the molecular mechanisms involved in this process remain poorly understood...

    Maria Vega-Sendino, Felipe F. Lüttmann, Teresa Olbrich, Yanpu Chen… in Nature Genetics (2024)

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    Article

    OBOX regulates mouse zygotic genome activation and early development

    Zygotic genome activation (ZGA) activates the quiescent genome to enable the maternal-to-zygotic transition1,2. However, the identity of transcription factors that underlie mammalian ZGA in vivo remains elusive. ...

    Shuyan Ji, Fengling Chen, Paula Stein, Jiacheng Wang, Ziming Zhou, Lijuan Wang… in Nature (2023)

  3. No Access

    Article

    p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models

    In mammalian embryos, proper zygotic genome activation (ZGA) underlies totipotent development. Double homeobox (DUX)-family factors participate in ZGA, and mouse Dux is required for forming cultured two-cell (2C)...

    Edward J. Grow, Bradley D. Weaver, Christina M. Smith, **gtao Guo… in Nature Genetics (2021)

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    Protocol

    RNAi-Based Methods for Gene Silencing in Mouse Oocytes

    RNA interference (RNAi) is an evolutionary conserved gene-silencing pathway that can be efficiently utilized as a tool to study gene function. RNAi is initiated by long double-stranded RNAs (dsRNAs), which are...

    Paula Stein, Petr Svoboda, Richard M. Schultz in Mammalian Oocyte Regulation (2013)

  5. No Access

    Article

    Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

    Over evolutionary time, many genes undergo duplication and one copy accumulates mutations that render it non-functional. These 'pseudogenes' are generally thought to be rather uninteresting, dead-end pieces of...

    Oliver H. Tam, Alexei A. Aravin, Paula Stein, Angelique Girard… in Nature (2008)

  6. No Access

    Article

    Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation

    In a wide variety of animal species, oocyte maturation is arrested temporarily at prophase of meiosis I (ref. 1). Resumption of meiosis requires activation of cyclin-dependent kinase-1 (CDK1, p34cdc2), one compon...

    A. Jeannine Lincoln, Dineli Wickramasinghe, Paula Stein… in Nature Genetics (2002)